| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 22 | 22 | 6 | 9 | 4.21 | .300 | 1.23 | 8.6 | 2.5 | 8.8 | 143.1 | 137 | 70 | 67 | 19 | 40 | 140 | 1 | 0 | 0 | 0 | 13 | 7 | 3 | 3.76 |
| SP | Peralta, F.Peralta, Freddy † >> | 29 | 2025 | R | 87 | 21 | 21 | 13 | 2 | 2.12 | .258 | 1.03 | 5.8 | 3.5 | 12.2 | 127.1 | 82 | 31 | 30 | 8 | 49 | 172 | 0 | 0 | 0 | 0 | 14 | 2 | 0 | 2.31 |
| SP | Horton, C.Horton, Cade # >> | 23 | 2025 | R | 76 | 21 | 21 | 6 | 8 | 5.15 | .329 | 1.40 | 8.8 | 3.8 | 8.0 | 108.1 | 106 | 63 | 62 | 26 | 46 | 96 | 0 | 0 | 0 | 0 | 3 | 7 | 4 | 5.82 |
| CL | Miller, M.Miller, Mason † >> | 26 | 2025 | R | 98 | 51 | 0 | 3 | 5 | 2.60 | .274 | 1.10 | 6.2 | 3.6 | 12.6 | 52.0 | 36 | 16 | 15 | 2 | 21 | 73 | 0 | 25 | 3 | 0 | 0 | 2 | 1 | 2.02 |
| SU | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 47 | 0 | 3 | 3 | 2.68 | .298 | 1.25 | 7.0 | 4.3 | 8.5 | 50.1 | 39 | 15 | 15 | 3 | 24 | 47 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 3.40 |
| RP | Weaver, L.Weaver, Luke >> | 31 | 2025 | R | 85 | 57 | 0 | 5 | 2 | 2.60 | .267 | 1.06 | 6.7 | 2.9 | 10.2 | 62.1 | 46 | 18 | 18 | 8 | 20 | 70 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 3.48 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 78 | 52 | 0 | 2 | 1 | 3.02 | .285 | 1.17 | 6.5 | 4.2 | 11.1 | 47.2 | 34 | 16 | 16 | 5 | 22 | 58 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 3.38 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 65 | 0 | 2 | 1 | 3.55 | .309 | 1.28 | 8.1 | 3.6 | 9.0 | 50.2 | 45 | 20 | 20 | 5 | 20 | 50 | 0 | 1 | 4 | 0 | 0 | 3 | 3 | 3.68 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 61 | 17 | 2 | 1 | 1 | 5.50 | .335 | 1.45 | 11.1 | 2.1 | 9.9 | 52.1 | 64 | 32 | 32 | 7 | 12 | 57 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 3.42 |