| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 32 | 32 | 10 | 13 | 4.61 | .326 | 1.42 | 10.0 | 2.8 | 9.9 | 191.1 | 212 | 100 | 98 | 24 | 60 | 211 | 0 | 0 | 0 | 0 | 18 | 6 | 3 | 3.46 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 31 | 31 | 3 | 19 | 7.09 | .372 | 1.76 | 11.7 | 4.2 | 9.2 | 166.1 | 215 | 132 | 131 | 34 | 78 | 169 | 0 | 0 | 0 | 0 | 9 | 3 | 7 | 5.09 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 66 | 31 | 31 | 8 | 13 | 5.77 | .351 | 1.60 | 10.3 | 4.1 | 10.4 | 149.2 | 171 | 96 | 96 | 28 | 68 | 173 | 0 | 0 | 0 | 0 | 7 | 4 | 6 | 4.57 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 62 | 32 | 31 | 8 | 16 | 6.72 | .367 | 1.67 | 11.6 | 3.5 | 9.1 | 148.2 | 191 | 117 | 111 | 30 | 57 | 149 | 0 | 0 | 0 | 0 | 8 | 11 | 1 | 5.00 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 32 | 31 | 11 | 13 | 5.08 | .326 | 1.40 | 8.6 | 4.0 | 8.2 | 184.1 | 176 | 108 | 104 | 23 | 82 | 168 | 1 | 0 | 0 | 0 | 13 | 9 | 10 | 4.28 |
| RP | Okert, S.Okert, Steven >> | 33 | 2025 | L | 97 | 106 | 0 | 6 | 3 | 4.23 | .324 | 1.41 | 9.3 | 3.4 | 10.1 | 134.0 | 138 | 67 | 63 | 18 | 51 | 151 | 0 | 5 | 8 | 0 | 0 | 4 | 0 | 3.72 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 95 | 0 | 5 | 5 | 3.44 | .315 | 1.36 | 7.4 | 4.9 | 10.9 | 120.1 | 99 | 47 | 46 | 10 | 65 | 145 | 0 | 6 | 3 | 0 | 0 | 2 | 12 | 3.34 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 97 | 0 | 5 | 3 | 4.27 | .305 | 1.29 | 8.1 | 3.6 | 9.1 | 116.0 | 104 | 58 | 55 | 19 | 46 | 117 | 0 | 8 | 2 | 0 | 0 | 3 | 0 | 4.38 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 73 | 0 | 8 | 3 | 3.67 | .321 | 1.38 | 9.1 | 3.4 | 11.2 | 83.1 | 84 | 35 | 34 | 9 | 31 | 103 | 0 | 4 | 1 | 0 | 0 | 3 | 4 | 3.16 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 71 | 68 | 0 | 3 | 1 | 3.04 | .263 | 1.05 | 6.5 | 3.0 | 7.4 | 91.2 | 66 | 33 | 31 | 10 | 30 | 75 | 0 | 6 | 0 | 0 | 0 | 2 | 2 | 3.84 |