| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 5 | 5 | 1 | 2 | 6.08 | .375 | 1.80 | 12.5 | 4.2 | 11.4 | 26.2 | 36 | 18 | 18 | 2 | 12 | 33 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2.85 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 5 | 5 | 0 | 3 | 5.14 | .333 | 1.50 | 9.6 | 3.9 | 9.6 | 28.0 | 30 | 16 | 16 | 5 | 12 | 30 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.46 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 66 | 5 | 5 | 1 | 3 | 6.45 | .407 | 2.01 | 11.9 | 6.5 | 9.4 | 22.1 | 29 | 16 | 16 | 6 | 16 | 23 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 6.77 |
| SP | Castillo, L.Castillo, Luis >> | 32 | 2025 | R | 62 | 5 | 5 | 2 | 1 | 4.74 | .357 | 1.50 | 9.8 | 4.1 | 7.1 | 24.2 | 26 | 13 | 13 | 4 | 11 | 19 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 5.46 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 4 | 4 | 2 | 1 | 5.03 | .298 | 1.27 | 8.1 | 3.8 | 9.0 | 19.2 | 17 | 11 | 11 | 2 | 8 | 19 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 3.63 |
| RP | Okert, S.Okert, Steven >> | 33 | 2025 | L | 97 | 18 | 0 | 0 | 0 | 6.30 | .388 | 1.80 | 13.1 | 3.2 | 9.5 | 20.0 | 29 | 16 | 14 | 3 | 7 | 21 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.20 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 16 | 0 | 1 | 2 | 5.21 | .305 | 1.26 | 7.1 | 4.3 | 11.8 | 19.0 | 15 | 12 | 11 | 3 | 9 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.00 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 14 | 0 | 0 | 1 | 5.23 | .311 | 1.31 | 8.6 | 3.6 | 8.6 | 20.2 | 19 | 12 | 12 | 2 | 8 | 19 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.75 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 14 | 0 | 3 | 0 | 1.98 | .349 | 1.54 | 9.7 | 4.8 | 14.5 | 13.2 | 14 | 3 | 3 | 0 | 7 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 1.62 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 71 | 13 | 0 | 1 | 0 | 0.48 | .253 | 1.02 | 4.5 | 5.0 | 8.0 | 18.2 | 9 | 1 | 1 | 1 | 10 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.61 |