| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 88 | 23 | 23 | 4 | 10 | 6.20 | .357 | 1.64 | 10.3 | 4.6 | 9.5 | 98.2 | 112 | 68 | 68 | 16 | 50 | 103 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 4.61 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 22 | 22 | 5 | 8 | 3.40 | .290 | 1.17 | 8.2 | 2.4 | 10.4 | 140.1 | 127 | 55 | 53 | 16 | 37 | 162 | 1 | 0 | 0 | 0 | 14 | 8 | 4 | 3.14 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 87 | 21 | 21 | 6 | 8 | 3.00 | .298 | 1.22 | 6.5 | 4.5 | 10.2 | 114.0 | 82 | 39 | 38 | 8 | 57 | 129 | 0 | 0 | 0 | 0 | 8 | 6 | 4 | 3.31 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 19 | 19 | 4 | 4 | 4.73 | .331 | 1.45 | 9.4 | 3.7 | 9.9 | 97.0 | 101 | 51 | 51 | 14 | 40 | 107 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 4.00 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 54 | 0 | 7 | 3 | 2.24 | .256 | 1.03 | 7.0 | 2.4 | 9.5 | 76.1 | 59 | 19 | 19 | 4 | 20 | 80 | 0 | 2 | 4 | 0 | 0 | 0 | 2 | 2.37 |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 51 | 0 | 5 | 3 | 2.70 | .286 | 1.17 | 7.1 | 3.5 | 10.1 | 66.2 | 52 | 20 | 20 | 4 | 26 | 74 | 0 | 6 | 3 | 0 | 0 | 2 | 1 | 2.82 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 24 | 0 | 3 | 2 | 4.03 | .298 | 1.28 | 9.0 | 2.5 | 10.9 | 29.0 | 29 | 13 | 13 | 5 | 8 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.66 |
| SP | Bello, B.Bello, Brayan >> | 26 | 2025 | R | 55 | 18 | 0 | 6 | 2 | 3.25 | .310 | 1.29 | 7.9 | 3.8 | 8.8 | 72.0 | 63 | 27 | 26 | 6 | 30 | 70 | 0 | 1 | 0 | 0 | 0 | 4 | 4 | 3.56 |