| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 29 | 29 | 7 | 17 | 3.38 | .284 | 1.17 | 8.6 | 2.0 | 10.0 | 197.1 | 188 | 79 | 74 | 29 | 43 | 218 | 1 | 0 | 0 | 0 | 18 | 4 | 3 | 3.42 |
| SP | Rasmussen, D.Rasmussen, Drew # >> | 29 | 2025 | R | 84 | 28 | 28 | 11 | 7 | 4.40 | .284 | 1.16 | 8.2 | 2.3 | 8.1 | 151.1 | 138 | 75 | 74 | 24 | 38 | 136 | 0 | 0 | 0 | 0 | 9 | 4 | 3 | 4.10 |
| SP | Gausman, K.Gausman, Kevin # >> | 34 | 2025 | R | 82 | 28 | 28 | 9 | 13 | 5.29 | .332 | 1.48 | 10.2 | 3.1 | 9.5 | 166.2 | 188 | 102 | 98 | 24 | 58 | 175 | 0 | 0 | 0 | 0 | 13 | 2 | 4 | 3.86 |
| SP | Abbott, A.Abbott, Andrew † >> | 26 | 2025 | L | 67 | 27 | 27 | 11 | 7 | 4.32 | .316 | 1.36 | 9.6 | 2.7 | 7.8 | 162.1 | 173 | 82 | 78 | 29 | 48 | 141 | 1 | 0 | 0 | 0 | 15 | 4 | 5 | 4.55 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 64 | 26 | 26 | 6 | 14 | 5.89 | .382 | 1.82 | 11.6 | 4.8 | 8.7 | 136.0 | 175 | 96 | 89 | 14 | 73 | 132 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.10 |
| RP | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 71 | 0 | 3 | 4 | 4.29 | .326 | 1.43 | 8.4 | 4.5 | 11.1 | 86.0 | 80 | 41 | 41 | 4 | 43 | 106 | 0 | 5 | 4 | 0 | 0 | 2 | 0 | 2.71 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 65 | 0 | 6 | 4 | 4.62 | .341 | 1.51 | 10.2 | 3.4 | 10.8 | 74.0 | 84 | 42 | 38 | 5 | 28 | 89 | 0 | 8 | 7 | 0 | 0 | 3 | 1 | 2.73 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 64 | 58 | 0 | 2 | 4 | 4.13 | .342 | 1.52 | 9.3 | 4.4 | 12.8 | 61.0 | 63 | 34 | 28 | 8 | 30 | 87 | 0 | 6 | 1 | 0 | 0 | 2 | 1 | 3.43 |
| RP | Phillips, T.Phillips, Tyler >> | 27 | 2025 | R | 55 | 52 | 0 | 1 | 4 | 6.15 | .353 | 1.59 | 10.5 | 3.9 | 8.5 | 67.1 | 78 | 48 | 46 | 13 | 29 | 63 | 0 | 5 | 2 | 0 | 0 | 3 | 5 | 5.07 |
| SP | Bello, B.Bello, Brayan >> | 26 | 2025 | R | 55 | 2 | 1 | 0 | 0 | 5.06 | .385 | 1.88 | 16.2 | 1.8 | 9.0 | 5.1 | 9 | 3 | 3 | 1 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.20 |