| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 36 | 36 | 22 | 5 | 3.05 | .253 | 1.00 | 7.1 | 1.9 | 10.0 | 241.2 | 190 | 90 | 82 | 24 | 52 | 268 | 1 | 0 | 0 | 1 | 28 | 3 | 1 | 2.76 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 78 | 36 | 36 | 10 | 9 | 4.68 | .319 | 1.40 | 9.1 | 3.5 | 8.0 | 173.0 | 174 | 99 | 90 | 33 | 68 | 154 | 0 | 0 | 0 | 0 | 13 | 1 | 4 | 4.90 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 77 | 32 | 32 | 6 | 5 | 4.47 | .314 | 1.31 | 7.7 | 4.1 | 9.1 | 135.0 | 116 | 72 | 67 | 21 | 61 | 136 | 0 | 0 | 0 | 0 | 2 | 8 | 3 | 4.54 |
| SP | Nelson, R.Nelson, Ryne # >> | 27 | 2025 | R | 79 | 32 | 30 | 1 | 7 | 4.84 | .327 | 1.45 | 9.7 | 3.5 | 8.0 | 109.2 | 117 | 60 | 59 | 22 | 42 | 97 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 5.03 |
| RP | Pagan, E.Pagan, Emilio # >> | 34 | 2025 | R | 95 | 110 | 0 | 12 | 3 | 4.13 | .291 | 1.17 | 7.7 | 2.9 | 10.4 | 124.1 | 106 | 60 | 57 | 13 | 40 | 143 | 0 | 2 | 3 | 0 | 0 | 7 | 4 | 3.19 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 109 | 0 | 6 | 3 | 3.39 | .270 | 1.10 | 7.4 | 2.5 | 8.6 | 103.2 | 85 | 41 | 39 | 15 | 29 | 98 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.86 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 100 | 0 | 8 | 3 | 2.41 | .294 | 1.18 | 6.3 | 4.4 | 9.3 | 104.2 | 73 | 29 | 28 | 7 | 51 | 108 | 0 | 4 | 7 | 0 | 0 | 7 | 2 | 3.47 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 78 | 79 | 0 | 8 | 5 | 4.37 | .312 | 1.30 | 7.8 | 4.0 | 10.5 | 82.1 | 71 | 42 | 40 | 11 | 36 | 96 | 0 | 6 | 4 | 0 | 0 | 5 | 0 | 3.90 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 72 | 71 | 0 | 5 | 5 | 3.31 | .290 | 1.23 | 6.9 | 4.2 | 8.4 | 73.1 | 56 | 29 | 27 | 8 | 34 | 68 | 0 | 10 | 8 | 0 | 0 | 0 | 3 | 3.96 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 107 | 0 | 7 | 3 | 3.02 | .280 | 1.14 | 7.5 | 2.8 | 7.8 | 83.1 | 69 | 28 | 28 | 8 | 26 | 72 | 0 | 4 | 3 | 0 | 0 | 2 | 1 | 3.53 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 50 | 0 | 5 | 2 | 1.83 | .213 | 0.81 | 5.6 | 1.7 | 7.3 | 64.0 | 40 | 17 | 13 | 3 | 12 | 52 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 2.55 |