| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 29 | 29 | 10 | 9 | 3.76 | .286 | 1.19 | 8.4 | 2.3 | 9.2 | 189.0 | 176 | 80 | 79 | 14 | 48 | 194 | 2 | 0 | 0 | 1 | 18 | 3 | 3 | 2.72 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 80 | 27 | 27 | 9 | 7 | 4.35 | .353 | 1.59 | 10.8 | 3.6 | 9.9 | 157.1 | 188 | 80 | 76 | 23 | 62 | 172 | 0 | 0 | 0 | 0 | 13 | 7 | 3 | 4.03 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 57 | 27 | 27 | 5 | 9 | 5.23 | .322 | 1.41 | 8.8 | 3.9 | 7.6 | 118.2 | 116 | 69 | 69 | 23 | 51 | 100 | 0 | 0 | 0 | 0 | 6 | 2 | 4 | 5.19 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 91 | 0 | 1 | 3 | 5.63 | .357 | 1.66 | 9.9 | 5.1 | 6.6 | 70.1 | 77 | 44 | 44 | 9 | 40 | 51 | 0 | 2 | 6 | 0 | 0 | 0 | 7 | 4.93 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 74 | 70 | 0 | 3 | 2 | 3.56 | .305 | 1.26 | 7.8 | 3.6 | 7.4 | 78.1 | 68 | 31 | 31 | 8 | 31 | 64 | 0 | 0 | 5 | 0 | 0 | 4 | 1 | 4.04 |
| SP | Rodon, C.Rodon, Carlos >> | 32 | 2025 | L | 91 | 44 | 0 | 9 | 7 | 3.24 | .324 | 1.37 | 7.6 | 4.8 | 9.5 | 72.1 | 61 | 26 | 26 | 8 | 38 | 76 | 0 | 4 | 4 | 0 | 0 | 5 | 1 | 4.13 |