| SP | Brown, H.Brown, Hunter >> | 26 | 2025 | R | 92 | 25 | 25 | 8 | 11 | 3.40 | .299 | 1.25 | 7.7 | 3.6 | 10.4 | 156.0 | 133 | 66 | 59 | 12 | 62 | 180 | 0 | 0 | 0 | 0 | 15 | 5 | 0 | 2.98 |
| SP | Cabrera, E.Cabrera, Edward # >> | 27 | 2025 | R | 66 | 24 | 24 | 7 | 10 | 5.20 | .314 | 1.36 | 9.5 | 2.7 | 10.0 | 133.1 | 141 | 81 | 77 | 29 | 40 | 148 | 0 | 0 | 0 | 0 | 5 | 2 | 6 | 4.56 |
| SP | Littell, Z.Littell, Zack # >> | 29 | 2025 | R | 60 | 24 | 24 | 5 | 12 | 5.96 | .324 | 1.42 | 10.4 | 2.5 | 7.8 | 139.0 | 160 | 93 | 92 | 36 | 38 | 120 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 5.50 |
| SP | Wacha, M.Wacha, Michael >> | 33 | 2025 | R | 45 | 23 | 23 | 11 | 5 | 4.67 | .344 | 1.53 | 10.4 | 3.3 | 7.1 | 131.0 | 152 | 68 | 68 | 23 | 48 | 103 | 0 | 0 | 0 | 0 | 9 | 6 | 1 | 4.95 |
| SP | Scherzer, M.Scherzer, Max >> | 41 | 2025 | R | 32 | 23 | 23 | 4 | 10 | 5.43 | .365 | 1.68 | 10.8 | 4.3 | 8.4 | 114.1 | 137 | 75 | 69 | 16 | 55 | 106 | 0 | 0 | 0 | 0 | 4 | 5 | 3 | 4.54 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 71 | 64 | 0 | 1 | 6 | 3.06 | .310 | 1.30 | 6.2 | 5.5 | 6.7 | 85.1 | 59 | 32 | 29 | 9 | 52 | 63 | 0 | 3 | 1 | 0 | 0 | 4 | 2 | 4.87 |
| RP | Ferguson, T.Ferguson, Tyler >> | 31 | 2025 | R | 45 | 54 | 0 | 2 | 5 | 4.48 | .349 | 1.59 | 8.3 | 6.2 | 7.2 | 60.1 | 55 | 30 | 30 | 6 | 41 | 48 | 0 | 7 | 2 | 0 | 0 | 1 | 1 | 4.80 |
| RP | Kelly, M.Kelly, Michael >> | 32 | 2025 | R | 36 | 46 | 0 | 2 | 2 | 2.56 | .307 | 1.33 | 8.0 | 4.2 | 8.5 | 52.2 | 46 | 15 | 15 | 4 | 24 | 49 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Peterson, D.Peterson, David >> | 29 | 2025 | L | 21 | 15 | 0 | 1 | 4 | 4.34 | .371 | 1.66 | 12.5 | 3.0 | 6.5 | 18.2 | 25 | 11 | 9 | 1 | 6 | 13 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.61 |