| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 4 | 4 | 1 | 1 | 4.01 | .308 | 1.34 | 10.1 | 2.3 | 10.9 | 24.2 | 27 | 13 | 11 | 5 | 6 | 29 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.04 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 78 | 3 | 3 | 1 | 0 | 5.65 | .348 | 1.53 | 10.3 | 3.9 | 7.7 | 14.1 | 16 | 10 | 9 | 2 | 6 | 12 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.64 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 3 | 3 | 1 | 1 | 4.12 | .337 | 1.53 | 11.4 | 2.8 | 4.3 | 19.2 | 24 | 9 | 9 | 3 | 6 | 9 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 5.05 |
| SP | Kershaw, C.Kershaw, Clayton >> | 37 | 2025 | L | 57 | 5 | 3 | 1 | 1 | 7.30 | .403 | 2.03 | 14.3 | 4.5 | 3.8 | 12.1 | 19 | 11 | 10 | 2 | 6 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.83 |
| CL | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 9 | 0 | 2 | 2 | 4.63 | .407 | 2.06 | 10.6 | 9.0 | 7.4 | 11.2 | 13 | 6 | 6 | 1 | 11 | 9 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5.55 |
| SU | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 87 | 10 | 0 | 0 | 0 | 4.63 | .286 | 1.20 | 6.5 | 4.9 | 11.5 | 11.2 | 8 | 6 | 6 | 3 | 6 | 14 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.64 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 7 | 0 | 0 | 0 | 3.60 | .333 | 1.50 | 7.2 | 6.3 | 12.6 | 10.0 | 8 | 4 | 4 | 2 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.90 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 11 | 0 | 1 | 0 | 6.52 | .453 | 2.48 | 13.0 | 11.0 | 6.0 | 9.2 | 13 | 7 | 7 | 2 | 11 | 6 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 8.22 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 11 | 0 | 2 | 0 | 0.00 | .136 | 0.47 | 2.3 | 2.3 | 12.0 | 12.2 | 3 | 0 | 0 | 0 | 3 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.08 |