| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 31 | 31 | 10 | 12 | 4.36 | .316 | 1.35 | 9.7 | 2.5 | 11.2 | 192.0 | 206 | 101 | 93 | 22 | 54 | 239 | 1 | 0 | 0 | 1 | 17 | 6 | 5 | 2.94 |
| SP | Cameron, N.Cameron, Noah # >> | 25 | 2025 | L | 78 | 30 | 30 | 13 | 6 | 3.70 | .292 | 1.19 | 7.7 | 3.1 | 8.4 | 185.0 | 158 | 79 | 76 | 15 | 63 | 172 | 0 | 0 | 0 | 0 | 16 | 8 | 5 | 3.35 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 82 | 30 | 30 | 13 | 12 | 3.91 | .303 | 1.28 | 8.6 | 2.9 | 7.1 | 193.1 | 185 | 86 | 84 | 34 | 63 | 153 | 0 | 0 | 0 | 0 | 18 | 4 | 4 | 4.75 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 37 | 2025 | L | 57 | 32 | 29 | 7 | 7 | 6.14 | .358 | 1.66 | 10.7 | 4.2 | 8.3 | 132.0 | 157 | 93 | 90 | 21 | 62 | 121 | 0 | 1 | 0 | 0 | 2 | 2 | 6 | 4.69 |
| CL | Santana, D.Santana, Dennis † >> | 29 | 2025 | R | 92 | 71 | 0 | 4 | 10 | 4.17 | .325 | 1.38 | 9.1 | 3.4 | 7.6 | 77.2 | 78 | 43 | 36 | 10 | 29 | 65 | 0 | 25 | 3 | 0 | 0 | 5 | 0 | 4.32 |
| SU | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 87 | 89 | 0 | 1 | 2 | 2.91 | .303 | 1.27 | 7.6 | 3.8 | 10.2 | 96.0 | 81 | 33 | 31 | 11 | 41 | 109 | 0 | 7 | 6 | 0 | 0 | 3 | 3 | 3.59 |
| RP | Bednar, D.Bednar, David † >> | 30 | 2025 | R | 79 | 93 | 0 | 7 | 2 | 3.03 | .271 | 1.10 | 6.8 | 3.1 | 10.3 | 113.0 | 85 | 38 | 38 | 14 | 39 | 129 | 0 | 4 | 1 | 0 | 0 | 2 | 9 | 3.42 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 87 | 0 | 4 | 6 | 7.18 | .365 | 1.70 | 9.6 | 5.7 | 10.7 | 79.0 | 84 | 64 | 63 | 16 | 50 | 94 | 0 | 2 | 5 | 0 | 0 | 2 | 3 | 5.23 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 98 | 0 | 6 | 2 | 2.31 | .287 | 1.14 | 7.4 | 3.0 | 7.9 | 93.2 | 76 | 24 | 24 | 10 | 31 | 82 | 0 | 3 | 0 | 0 | 0 | 6 | 2 | 3.83 |