| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 36 | 36 | 18 | 11 | 3.29 | .252 | 0.97 | 7.0 | 1.8 | 11.0 | 246.1 | 191 | 92 | 90 | 25 | 49 | 300 | 3 | 0 | 0 | 1 | 24 | 9 | 2 | 2.59 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 86 | 33 | 33 | 12 | 10 | 3.60 | .310 | 1.33 | 7.3 | 4.7 | 10.2 | 172.2 | 140 | 69 | 69 | 13 | 89 | 194 | 0 | 0 | 0 | 0 | 7 | 4 | 6 | 3.35 |
| SP | Pepiot, R.Pepiot, Ryan # >> | 27 | 2025 | R | 77 | 33 | 33 | 11 | 7 | 5.34 | .324 | 1.43 | 9.7 | 3.1 | 10.3 | 182.0 | 197 | 112 | 108 | 24 | 63 | 209 | 0 | 0 | 0 | 0 | 15 | 2 | 3 | 3.49 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 67 | 31 | 31 | 12 | 10 | 4.18 | .309 | 1.29 | 8.6 | 3.0 | 7.4 | 194.0 | 186 | 90 | 90 | 18 | 65 | 159 | 1 | 0 | 0 | 0 | 16 | 9 | 5 | 3.71 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 71 | 0 | 5 | 6 | 1.67 | .220 | 0.85 | 5.0 | 2.6 | 12.0 | 75.2 | 42 | 14 | 14 | 3 | 22 | 100 | 0 | 48 | 3 | 0 | 0 | 0 | 1 | 1.73 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 87 | 86 | 0 | 2 | 1 | 2.34 | .294 | 1.23 | 7.3 | 3.8 | 9.4 | 104.0 | 84 | 27 | 27 | 5 | 44 | 109 | 0 | 1 | 3 | 0 | 0 | 2 | 4 | 2.86 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 57 | 0 | 2 | 2 | 3.93 | .333 | 1.42 | 8.3 | 4.7 | 9.7 | 52.2 | 48 | 24 | 23 | 9 | 27 | 56 | 0 | 1 | 3 | 0 | 0 | 4 | 1 | 4.88 |
| RP | Holton, T.Holton, Tyler >> | 29 | 2025 | L | 63 | 44 | 0 | 4 | 1 | 2.18 | .244 | 0.91 | 6.1 | 2.2 | 8.3 | 53.2 | 36 | 15 | 13 | 3 | 13 | 49 | 0 | 1 | 0 | 0 | 0 | 3 | 2 | 2.79 |
| SP | Littell, Z.Littell, Zack >> | 29 | 2025 | R | 60 | 23 | 0 | 6 | 2 | 4.81 | .296 | 1.23 | 9.0 | 2.0 | 7.6 | 88.0 | 88 | 48 | 47 | 12 | 20 | 74 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.88 |