| SP | Skubal, T.Skubal, Tarik † $$ >> | 28 | 2025 | L | 100 | 34 | 34 | 15 | 11 | 3.36 | .283 | 1.16 | 7.8 | 2.6 | 10.9 | 217.0 | 188 | 84 | 81 | 23 | 63 | 263 | 1 | 0 | 0 | 0 | 21 | 6 | 4 | 2.91 |
| SP | Perez, E.Perez, Eury † >> | 22 | 2025 | R | 89 | 32 | 32 | 15 | 4 | 2.82 | .284 | 1.17 | 6.8 | 3.7 | 10.7 | 166.0 | 126 | 60 | 52 | 13 | 69 | 197 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 2.95 |
| SP | Schwellenbach, S.Schwellenbach, Spencer † $ >> | 25 | 2025 | R | 85 | 33 | 33 | 17 | 10 | 4.05 | .309 | 1.31 | 9.6 | 2.2 | 8.0 | 218.0 | 232 | 110 | 98 | 37 | 54 | 194 | 0 | 0 | 0 | 0 | 21 | 6 | 3 | 4.25 |
| SP | Mahle, T.Mahle, Tyler # >> | 30 | 2025 | R | 71 | 31 | 31 | 13 | 5 | 4.25 | .308 | 1.30 | 8.4 | 3.3 | 7.7 | 175.2 | 164 | 85 | 83 | 25 | 64 | 149 | 0 | 0 | 0 | 0 | 11 | 7 | 0 | 4.37 |
| CL | Chapman, A.Chapman, Aroldis † $ >> | 37 | 2025 | L | 100 | 65 | 0 | 2 | 5 | 2.25 | .212 | 0.79 | 5.3 | 1.9 | 9.9 | 68.0 | 40 | 17 | 17 | 8 | 14 | 75 | 0 | 44 | 1 | 0 | 0 | 1 | 2 | 2.99 |
| SU | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 72 | 0 | 2 | 2 | 2.97 | .261 | 1.02 | 6.7 | 2.5 | 8.3 | 75.2 | 56 | 27 | 25 | 12 | 21 | 69 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 4.20 |
| RP | Coulombe, D.Coulombe, Daniel >> | 35 | 2025 | L | 65 | 97 | 0 | 1 | 2 | 2.17 | .270 | 1.07 | 6.8 | 2.9 | 10.0 | 74.2 | 56 | 22 | 18 | 7 | 24 | 82 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 3.11 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 79 | 73 | 0 | 8 | 4 | 4.28 | .315 | 1.34 | 8.1 | 4.0 | 11.8 | 61.0 | 55 | 34 | 29 | 11 | 27 | 80 | 0 | 1 | 2 | 0 | 0 | 2 | 3 | 4.15 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 50 | 0 | 3 | 0 | 3.83 | .325 | 1.45 | 8.8 | 4.2 | 9.2 | 47.0 | 46 | 20 | 20 | 5 | 22 | 48 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.74 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 59 | 24 | 0 | 6 | 4 | 3.93 | .317 | 1.38 | 8.9 | 3.6 | 9.9 | 84.2 | 83 | 41 | 37 | 14 | 34 | 92 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 4.23 |