| SP | Skubal, T.Skubal, Tarik $ >> | 28 | 2025 | L | 100 | 36 | 36 | 14 | 8 | 3.46 | .284 | 1.15 | 8.3 | 2.1 | 9.9 | 239.0 | 221 | 92 | 92 | 18 | 55 | 263 | 1 | 0 | 0 | 1 | 20 | 9 | 6 | 2.58 |
| SP | Perez, E.Perez, Eury $ >> | 22 | 2025 | R | 89 | 35 | 35 | 8 | 3 | 3.10 | .298 | 1.26 | 7.5 | 3.9 | 10.5 | 180.0 | 150 | 63 | 62 | 12 | 77 | 210 | 0 | 0 | 0 | 0 | 4 | 2 | 13 | 2.85 |
| SP | Kershaw, C.Kershaw, Clayton † >> | 37 | 2025 | L | 57 | 31 | 31 | 9 | 4 | 4.26 | .322 | 1.39 | 8.9 | 3.6 | 8.3 | 152.0 | 151 | 75 | 72 | 14 | 61 | 140 | 0 | 0 | 0 | 0 | 4 | 5 | 5 | 3.66 |
| CL | Okert, S.Okert, Steven † >> | 33 | 2025 | L | 97 | 86 | 0 | 8 | 9 | 2.72 | .276 | 1.11 | 7.2 | 2.8 | 10.6 | 92.2 | 74 | 30 | 28 | 8 | 29 | 108 | 0 | 41 | 8 | 0 | 0 | 3 | 0 | 2.83 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 90 | 98 | 0 | 13 | 4 | 4.34 | .308 | 1.30 | 7.9 | 3.8 | 7.9 | 116.0 | 102 | 57 | 56 | 10 | 49 | 102 | 0 | 2 | 5 | 0 | 0 | 4 | 3 | 3.73 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 84 | 88 | 0 | 5 | 4 | 3.62 | .315 | 1.34 | 8.4 | 3.7 | 9.9 | 109.1 | 102 | 47 | 44 | 12 | 45 | 120 | 0 | 5 | 6 | 0 | 0 | 4 | 1 | 3.58 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 64 | 85 | 0 | 9 | 3 | 3.27 | .268 | 1.07 | 6.8 | 2.8 | 10.2 | 96.1 | 73 | 36 | 35 | 10 | 30 | 109 | 0 | 2 | 5 | 0 | 0 | 3 | 3 | 3.11 |
| RP | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 68 | 0 | 5 | 4 | 3.73 | .276 | 1.09 | 7.4 | 2.4 | 10.5 | 82.0 | 67 | 34 | 34 | 13 | 22 | 96 | 0 | 2 | 2 | 0 | 0 | 5 | 6 | 3.71 |