| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 19 | 19 | 8 | 5 | 2.92 | .276 | 1.13 | 8.2 | 2.0 | 11.1 | 132.2 | 120 | 43 | 43 | 10 | 30 | 163 | 1 | 0 | 0 | 1 | 15 | 2 | 3 | 2.24 |
| SP | Brown, H.Brown, Hunter >> | 26 | 2025 | R | 92 | 18 | 18 | 7 | 4 | 4.41 | .346 | 1.57 | 8.9 | 5.2 | 10.5 | 104.0 | 103 | 51 | 51 | 10 | 60 | 121 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 3.71 |
| SP | Kirby, G.Kirby, George # >> | 27 | 2025 | R | 61 | 17 | 17 | 3 | 5 | 4.53 | .292 | 1.23 | 8.5 | 2.5 | 11.2 | 99.1 | 94 | 50 | 50 | 21 | 28 | 123 | 1 | 0 | 0 | 1 | 6 | 1 | 0 | 4.15 |
| RP | Henriquez, R.Henriquez, Ronny >> | 25 | 2025 | R | 78 | 45 | 0 | 3 | 3 | 2.23 | .281 | 1.17 | 6.3 | 4.4 | 13.5 | 60.2 | 42 | 15 | 15 | 6 | 29 | 90 | 0 | 4 | 3 | 0 | 0 | 0 | 2 | 2.75 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 34 | 0 | 3 | 1 | 1.91 | .230 | 0.90 | 6.0 | 2.1 | 11.1 | 42.1 | 28 | 10 | 9 | 3 | 10 | 52 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 2.17 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 69 | 24 | 0 | 2 | 3 | 3.86 | .307 | 1.33 | 10.2 | 2.0 | 9.0 | 23.1 | 26 | 11 | 10 | 2 | 5 | 23 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 2.78 |
| RP | Koenig, J.Koenig, Jared >> | 31 | 2025 | L | 57 | 17 | 0 | 0 | 2 | 3.74 | .309 | 1.34 | 9.4 | 3.0 | 9.4 | 21.2 | 22 | 9 | 9 | 2 | 7 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.14 |