| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 7 | 7 | 2 | 4 | 4.07 | .318 | 1.40 | 10.3 | 2.4 | 8.6 | 48.2 | 55 | 22 | 22 | 7 | 13 | 46 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 3.79 |
| SP | Rodon, C.Rodon, Carlos >> | 32 | 2025 | L | 91 | 6 | 6 | 2 | 2 | 3.53 | .352 | 1.60 | 9.8 | 4.9 | 10.0 | 35.2 | 38 | 15 | 14 | 3 | 19 | 39 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.60 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 78 | 6 | 6 | 4 | 2 | 4.75 | .312 | 1.36 | 9.3 | 3.0 | 8.0 | 36.0 | 37 | 19 | 19 | 7 | 12 | 32 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 4.75 |
| RP | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 95 | 18 | 0 | 2 | 0 | 0.72 | .265 | 1.00 | 5.8 | 3.2 | 15.5 | 25.0 | 16 | 2 | 2 | 0 | 9 | 43 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0.88 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 20 | 0 | 1 | 1 | 5.24 | .356 | 1.61 | 10.6 | 4.1 | 9.0 | 22.1 | 26 | 13 | 13 | 6 | 10 | 22 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 6.05 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 9 | 0 | 0 | 0 | 6.00 | .357 | 1.56 | 10.0 | 4.0 | 9.0 | 9.0 | 10 | 6 | 6 | 4 | 4 | 9 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 8.44 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 64 | 10 | 0 | 0 | 1 | 5.59 | .396 | 1.97 | 11.0 | 8.0 | 14.0 | 9.2 | 11 | 6 | 6 | 0 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.56 |