| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 37 | 37 | 14 | 14 | 4.03 | .299 | 1.25 | 9.0 | 2.3 | 10.8 | 243.1 | 242 | 118 | 109 | 29 | 62 | 291 | 1 | 0 | 0 | 1 | 22 | 7 | 5 | 3.01 |
| SP | Rodon, C.Rodon, Carlos † >> | 32 | 2025 | L | 91 | 36 | 36 | 12 | 9 | 3.38 | .317 | 1.37 | 8.4 | 4.0 | 10.1 | 223.2 | 207 | 87 | 84 | 22 | 100 | 251 | 0 | 0 | 0 | 0 | 20 | 4 | 4 | 3.43 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 78 | 34 | 34 | 10 | 16 | 4.71 | .305 | 1.29 | 8.3 | 3.3 | 8.1 | 202.2 | 187 | 112 | 106 | 39 | 74 | 181 | 1 | 0 | 0 | 0 | 18 | 6 | 3 | 4.91 |
| RP | Rodríguez, R.Rodríguez, Randy >> | 25 | 2025 | R | 95 | 100 | 0 | 5 | 6 | 3.94 | .326 | 1.41 | 9.4 | 3.3 | 11.6 | 130.1 | 136 | 57 | 57 | 13 | 48 | 168 | 0 | 5 | 7 | 0 | 0 | 5 | 6 | 2.94 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 107 | 0 | 9 | 7 | 3.19 | .289 | 1.20 | 6.8 | 4.0 | 8.6 | 132.2 | 100 | 51 | 47 | 17 | 59 | 126 | 0 | 8 | 3 | 0 | 0 | 3 | 0 | 4.17 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 73 | 66 | 0 | 2 | 4 | 4.74 | .365 | 1.70 | 9.5 | 5.8 | 9.3 | 68.1 | 72 | 42 | 36 | 7 | 44 | 70 | 0 | 5 | 5 | 0 | 0 | 2 | 2 | 4.31 |
| RP | Estrada, J.Estrada, Jeremiah >> | 26 | 2025 | R | 64 | 57 | 0 | 5 | 4 | 4.76 | .325 | 1.43 | 8.1 | 4.8 | 12.5 | 62.1 | 56 | 36 | 33 | 14 | 33 | 86 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 4.81 |