| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 27 | 27 | 15 | 5 | 2.93 | .277 | 1.09 | 7.5 | 2.3 | 11.3 | 184.0 | 153 | 61 | 60 | 21 | 48 | 231 | 1 | 0 | 0 | 1 | 18 | 10 | 4 | 2.92 |
| SP | Gilbert, L.Gilbert, Logan # >> | 28 | 2025 | R | 91 | 27 | 27 | 9 | 7 | 3.76 | .288 | 1.18 | 8.2 | 2.4 | 10.5 | 153.1 | 140 | 65 | 64 | 16 | 41 | 178 | 0 | 0 | 0 | 0 | 11 | 5 | 6 | 2.93 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 80 | 26 | 26 | 4 | 11 | 5.37 | .332 | 1.49 | 9.1 | 4.3 | 9.7 | 137.1 | 138 | 82 | 82 | 24 | 66 | 148 | 0 | 0 | 0 | 0 | 8 | 1 | 7 | 4.58 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 68 | 26 | 26 | 6 | 11 | 6.07 | .335 | 1.49 | 9.8 | 3.6 | 10.7 | 139.1 | 152 | 94 | 94 | 32 | 55 | 165 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.89 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 66 | 28 | 25 | 6 | 7 | 6.20 | .380 | 1.80 | 11.9 | 4.3 | 10.2 | 126.1 | 167 | 88 | 87 | 16 | 60 | 143 | 0 | 2 | 0 | 0 | 4 | 5 | 6 | 3.93 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 82 | 89 | 0 | 9 | 6 | 3.94 | .296 | 1.19 | 7.1 | 3.6 | 7.9 | 109.2 | 86 | 48 | 48 | 9 | 44 | 96 | 0 | 5 | 2 | 0 | 0 | 8 | 6 | 3.74 |
| RP | Williams, D.Williams, Devin >> | 30 | 2025 | R | 76 | 77 | 0 | 2 | 1 | 3.70 | .311 | 1.36 | 8.4 | 3.8 | 11.3 | 90.0 | 84 | 38 | 37 | 8 | 38 | 113 | 0 | 3 | 5 | 0 | 0 | 0 | 4 | 2.91 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 70 | 0 | 9 | 2 | 3.31 | .293 | 1.23 | 7.6 | 3.5 | 9.3 | 84.1 | 71 | 34 | 31 | 7 | 33 | 87 | 0 | 1 | 4 | 0 | 0 | 1 | 5 | 3.23 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 90 | 69 | 0 | 3 | 4 | 5.01 | .343 | 1.56 | 9.0 | 5.0 | 11.7 | 79.0 | 79 | 44 | 44 | 13 | 44 | 103 | 0 | 4 | 5 | 0 | 0 | 1 | 0 | 4.24 |