| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 8 | 8 | 2 | 4 | 4.70 | .277 | 1.15 | 8.4 | 2.0 | 10.8 | 46.0 | 43 | 25 | 24 | 10 | 10 | 55 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 4.09 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 82 | 7 | 7 | 1 | 2 | 8.28 | .353 | 1.60 | 10.2 | 4.3 | 8.4 | 29.1 | 33 | 27 | 27 | 11 | 14 | 27 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 7.62 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 70 | 8 | 7 | 1 | 2 | 6.35 | .367 | 1.69 | 11.5 | 3.9 | 9.5 | 39.2 | 50 | 28 | 28 | 9 | 17 | 41 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 5.36 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 66 | 7 | 7 | 2 | 1 | 6.50 | .379 | 1.78 | 12.0 | 4.0 | 9.3 | 36.0 | 48 | 28 | 26 | 8 | 16 | 37 | 0 | 0 | 0 | 0 | 1 | 2 | 3 | 5.33 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 82 | 27 | 0 | 1 | 5 | 6.65 | .350 | 1.62 | 9.0 | 6.0 | 8.1 | 21.2 | 21 | 16 | 16 | 3 | 14 | 19 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 5.05 |
| RP | Williams, D.Williams, Devin >> | 30 | 2025 | R | 76 | 28 | 0 | 1 | 1 | 4.50 | .314 | 1.38 | 8.3 | 4.1 | 10.9 | 24.0 | 22 | 12 | 12 | 3 | 11 | 29 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 3.58 |
| RP | Rogers, T.Rogers, Tyler >> | 34 | 2025 | R | 68 | 22 | 0 | 2 | 3 | 2.60 | .252 | 1.01 | 8.3 | 1.0 | 7.3 | 27.2 | 25 | 10 | 8 | 4 | 3 | 22 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.63 |