| SP | Skubal, T.Skubal, Tarik † >> | 28 | 2025 | L | 100 | 28 | 28 | 14 | 4 | 1.95 | .254 | 1.00 | 6.9 | 2.1 | 10.5 | 198.2 | 151 | 45 | 43 | 14 | 47 | 232 | 1 | 0 | 0 | 1 | 22 | 5 | 2 | 2.36 |
| SP | Gilbert, L.Gilbert, Logan >> | 28 | 2025 | R | 91 | 28 | 28 | 5 | 14 | 5.45 | .345 | 1.53 | 10.7 | 3.2 | 10.2 | 140.1 | 166 | 85 | 85 | 23 | 49 | 159 | 0 | 0 | 0 | 0 | 4 | 7 | 12 | 4.06 |
| SP | Cameron, N.Cameron, Noah # >> | 25 | 2025 | L | 81 | 27 | 27 | 13 | 9 | 4.33 | .296 | 1.23 | 8.5 | 2.6 | 7.9 | 166.1 | 157 | 80 | 80 | 28 | 48 | 146 | 1 | 0 | 0 | 1 | 14 | 5 | 3 | 4.39 |
| SP | Springs, J.Springs, Jeffrey >> | 32 | 2025 | L | 67 | 28 | 26 | 9 | 4 | 4.14 | .312 | 1.32 | 8.6 | 3.3 | 7.4 | 152.1 | 145 | 70 | 70 | 22 | 56 | 125 | 0 | 0 | 0 | 0 | 13 | 6 | 0 | 4.46 |
| RP | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 83 | 0 | 9 | 5 | 2.59 | .279 | 1.13 | 6.9 | 3.4 | 10.3 | 114.2 | 87 | 34 | 33 | 7 | 43 | 131 | 0 | 7 | 1 | 0 | 0 | 3 | 13 | 2.71 |
| RP | Keller, B.Keller, Brad >> | 29 | 2025 | R | 90 | 77 | 0 | 8 | 6 | 2.92 | .291 | 1.22 | 7.1 | 3.9 | 9.7 | 101.2 | 80 | 34 | 33 | 8 | 44 | 109 | 0 | 6 | 9 | 0 | 0 | 1 | 1 | 3.21 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 74 | 0 | 5 | 3 | 4.73 | .325 | 1.43 | 9.6 | 3.4 | 9.8 | 91.1 | 97 | 48 | 48 | 16 | 34 | 99 | 0 | 9 | 6 | 0 | 0 | 1 | 0 | 4.26 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 65 | 0 | 4 | 2 | 3.80 | .325 | 1.40 | 8.6 | 4.1 | 9.7 | 73.1 | 70 | 34 | 31 | 8 | 33 | 79 | 0 | 8 | 2 | 0 | 0 | 3 | 2 | 3.74 |
| RP | Banks, T.Banks, Tanner >> | 33 | 2025 | L | 69 | 56 | 0 | 5 | 5 | 4.33 | .307 | 1.31 | 9.5 | 2.4 | 8.3 | 60.1 | 63 | 33 | 29 | 7 | 16 | 55 | 0 | 5 | 1 | 0 | 0 | 1 | 4 | 3.53 |