| SP | Skubal, T.Skubal, Tarik † # >> | 28 | 2025 | L | 100 | 23 | 23 | 9 | 8 | 3.39 | .282 | 1.16 | 8.4 | 2.1 | 10.2 | 156.2 | 145 | 59 | 59 | 17 | 36 | 177 | 3 | 0 | 0 | 3 | 15 | 4 | 2 | 2.92 |
| SP | Pepiot, R.Pepiot, Ryan >> | 27 | 2025 | R | 80 | 22 | 22 | 5 | 10 | 4.99 | .339 | 1.49 | 10.0 | 3.5 | 8.9 | 122.2 | 136 | 68 | 68 | 19 | 47 | 120 | 0 | 0 | 0 | 0 | 6 | 6 | 3 | 4.36 |
| RP | Rodríguez, R.Rodríguez, Randy † >> | 25 | 2025 | R | 96 | 61 | 0 | 9 | 3 | 2.64 | .315 | 1.34 | 8.3 | 3.8 | 10.6 | 78.1 | 72 | 23 | 23 | 4 | 33 | 92 | 0 | 6 | 3 | 0 | 0 | 3 | 4 | 2.69 |
| RP | Cleavinger, G.Cleavinger, Garrett >> | 31 | 2025 | L | 93 | 57 | 0 | 4 | 5 | 4.02 | .271 | 1.07 | 6.2 | 3.5 | 10.5 | 71.2 | 49 | 32 | 32 | 5 | 28 | 83 | 0 | 6 | 3 | 0 | 0 | 3 | 0 | 2.89 |
| RP | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 89 | 44 | 0 | 1 | 2 | 4.38 | .324 | 1.32 | 8.8 | 3.1 | 8.1 | 49.1 | 48 | 24 | 24 | 6 | 17 | 44 | 0 | 5 | 4 | 0 | 0 | 6 | 0 | 4.20 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 82 | 31 | 0 | 1 | 2 | 3.75 | .316 | 1.36 | 7.8 | 4.5 | 7.3 | 36.0 | 31 | 15 | 15 | 6 | 18 | 29 | 0 | 4 | 0 | 0 | 0 | 1 | 3 | 5.14 |
| RP | Koenig, J.Koenig, Jared # >> | 31 | 2025 | L | 57 | 27 | 0 | 0 | 1 | 5.26 | .289 | 1.19 | 7.3 | 3.6 | 10.2 | 37.2 | 30 | 22 | 22 | 4 | 15 | 42 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.43 |
| SP | Civale, A.Civale, Aaron >> | 30 | 2025 | R | 49 | 21 | 0 | 3 | 2 | 10.73 | .435 | 2.31 | 15.0 | 6.3 | 8.0 | 27.2 | 45 | 33 | 33 | 7 | 19 | 24 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.70 |