| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 21 | 21 | 8 | 9 | 3.12 | .291 | 1.17 | 8.4 | 2.1 | 9.8 | 141.1 | 132 | 49 | 49 | 13 | 33 | 154 | 3 | 0 | 0 | 1 | 13 | 9 | 2 | 2.91 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 20 | 20 | 6 | 3 | 2.74 | .295 | 1.26 | 7.6 | 3.8 | 10.3 | 108.1 | 91 | 35 | 33 | 11 | 45 | 124 | 0 | 0 | 0 | 0 | 6 | 0 | 4 | 3.28 |
| SP | Gausman, K.Gausman, Kevin # >> | 34 | 2025 | R | 84 | 20 | 20 | 10 | 5 | 3.84 | .309 | 1.29 | 9.1 | 2.5 | 9.9 | 122.0 | 123 | 60 | 52 | 20 | 34 | 134 | 0 | 0 | 0 | 0 | 9 | 7 | 1 | 3.94 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 82 | 20 | 20 | 4 | 5 | 4.83 | .309 | 1.31 | 9.3 | 2.6 | 7.8 | 100.2 | 103 | 55 | 54 | 15 | 29 | 87 | 0 | 0 | 0 | 0 | 3 | 3 | 3 | 4.17 |
| CL | Cleavinger, G.Cleavinger, Garrett † >> | 31 | 2025 | L | 93 | 62 | 0 | 8 | 5 | 4.52 | .294 | 1.25 | 7.8 | 3.6 | 10.5 | 65.2 | 56 | 33 | 33 | 8 | 26 | 76 | 0 | 20 | 3 | 0 | 0 | 0 | 2 | 3.46 |
| RP | Santana, D.Santana, Dennis † >> | 29 | 2025 | R | 92 | 63 | 0 | 10 | 3 | 4.66 | .277 | 1.14 | 7.9 | 2.4 | 8.2 | 87.0 | 76 | 46 | 45 | 15 | 23 | 79 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.25 |
| SU | Whitlock, G.Whitlock, Garrett >> | 29 | 2025 | R | 75 | 54 | 0 | 1 | 2 | 3.60 | .283 | 1.18 | 6.8 | 3.9 | 11.1 | 65.0 | 49 | 26 | 26 | 8 | 28 | 80 | 0 | 4 | 2 | 0 | 0 | 0 | 2 | 3.43 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 71 | 62 | 0 | 5 | 2 | 2.26 | .259 | 1.02 | 6.0 | 3.3 | 7.4 | 71.2 | 47 | 18 | 18 | 7 | 26 | 58 | 0 | 5 | 3 | 0 | 0 | 2 | 2 | 3.83 |