| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 23 | 23 | 8 | 5 | 3.78 | .314 | 1.34 | 8.4 | 3.7 | 11.2 | 116.2 | 108 | 49 | 49 | 6 | 48 | 144 | 0 | 0 | 0 | 0 | 5 | 4 | 6 | 2.53 |
| SP | Sale, C.Sale, Chris † # >> | 36 | 2025 | L | 85 | 22 | 22 | 12 | 3 | 3.22 | .284 | 1.18 | 8.0 | 2.7 | 10.6 | 139.2 | 124 | 50 | 50 | 17 | 41 | 163 | 0 | 0 | 0 | 0 | 17 | 1 | 4 | 3.15 |
| SP | Rasmussen, D.Rasmussen, Drew >> | 29 | 2025 | R | 86 | 22 | 22 | 7 | 8 | 4.79 | .308 | 1.31 | 8.6 | 3.2 | 7.3 | 103.1 | 98 | 58 | 55 | 18 | 37 | 84 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 4.81 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 84 | 22 | 22 | 9 | 4 | 5.50 | .348 | 1.58 | 11.0 | 3.2 | 8.0 | 113.0 | 138 | 71 | 69 | 18 | 40 | 100 | 0 | 0 | 0 | 0 | 9 | 3 | 2 | 4.44 |
| RP | Bautista, F.Bautista, Félix >> | 30 | 2025 | R | 85 | 60 | 0 | 5 | 2 | 2.85 | .324 | 1.43 | 6.0 | 7.0 | 11.0 | 75.2 | 50 | 26 | 24 | 4 | 58 | 92 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 3.60 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 58 | 0 | 6 | 1 | 2.92 | .262 | 1.05 | 6.3 | 3.2 | 9.9 | 77.0 | 54 | 27 | 25 | 5 | 27 | 85 | 0 | 6 | 2 | 0 | 0 | 1 | 3 | 2.73 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 71 | 50 | 0 | 3 | 2 | 3.94 | .288 | 1.20 | 7.2 | 3.7 | 7.3 | 59.1 | 47 | 26 | 26 | 8 | 24 | 48 | 0 | 7 | 4 | 0 | 0 | 1 | 2 | 4.41 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 69 | 43 | 0 | 3 | 3 | 3.06 | .286 | 1.20 | 6.7 | 4.1 | 7.6 | 50.0 | 37 | 17 | 17 | 4 | 23 | 42 | 0 | 9 | 2 | 0 | 0 | 0 | 0 | 3.74 |
| RP | Little, B.Little, Brendon >> | 28 | 2025 | L | 53 | 36 | 0 | 3 | 1 | 3.57 | .358 | 1.64 | 9.0 | 5.9 | 10.5 | 35.1 | 35 | 15 | 14 | 2 | 23 | 41 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.46 |
| RP | Romero, J.Romero, JoJo >> | 28 | 2025 | L | 52 | 29 | 0 | 1 | 1 | 3.77 | .345 | 1.58 | 9.9 | 4.4 | 7.5 | 31.0 | 34 | 14 | 13 | 3 | 15 | 26 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 4.03 |
| SP | Holmes, G.Holmes, Grant >> | 29 | 2025 | R | 45 | 20 | 0 | 7 | 1 | 3.82 | .325 | 1.39 | 8.6 | 4.0 | 10.8 | 75.1 | 72 | 33 | 32 | 11 | 33 | 90 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 3.99 |