| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 18 | 18 | 6 | 4 | 2.81 | .274 | 1.12 | 7.8 | 2.3 | 9.9 | 128.1 | 111 | 43 | 40 | 13 | 33 | 141 | 0 | 0 | 0 | 0 | 13 | 1 | 2 | 2.91 |
| SP | Littell, Z.Littell, Zack # >> | 29 | 2025 | R | 65 | 22 | 7 | 6 | 4 | 5.15 | .317 | 1.35 | 9.9 | 2.4 | 5.2 | 71.2 | 78 | 41 | 41 | 19 | 19 | 41 | 0 | 2 | 1 | 0 | 1 | 3 | 0 | 6.25 |
| CL | Miller, M.Miller, Mason >> | 26 | 2025 | R | 99 | 45 | 0 | 1 | 3 | 2.81 | .284 | 1.17 | 5.6 | 4.9 | 12.0 | 48.0 | 30 | 16 | 15 | 7 | 26 | 64 | 0 | 20 | 0 | 0 | 0 | 1 | 2 | 3.92 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 88 | 45 | 0 | 5 | 1 | 2.31 | .252 | 0.99 | 7.3 | 1.7 | 7.5 | 62.1 | 50 | 16 | 16 | 6 | 12 | 52 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.21 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 46 | 0 | 4 | 2 | 3.70 | .291 | 1.23 | 7.4 | 3.7 | 8.4 | 58.1 | 48 | 24 | 24 | 9 | 24 | 54 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.40 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 81 | 29 | 0 | 4 | 1 | 2.70 | .220 | 0.85 | 5.8 | 2.0 | 12.0 | 36.2 | 23 | 11 | 11 | 4 | 8 | 48 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 2.44 |