| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 100 | 25 | 25 | 7 | 6 | 0.37 | .115 | 0.39 | 2.8 | 0.7 | 9.5 | 221.1 | 68 | 9 | 9 | 2 | 18 | 233 | 7 | 0 | 0 | 4 | 25 | 0 | 4 | 1.25 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 96 | 25 | 25 | 10 | 8 | 0.40 | .131 | 0.44 | 3.1 | 0.9 | 8.7 | 227.1 | 78 | 12 | 10 | 0 | 23 | 219 | 15 | 0 | 0 | 7 | 25 | 2 | 2 | 1.40 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 98 | 56 | 0 | 2 | 3 | 0.32 | .111 | 0.36 | 2.7 | 0.5 | 10.0 | 56.0 | 17 | 3 | 2 | 0 | 3 | 62 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 1.00 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 90 | 37 | 0 | 2 | 2 | 0.16 | .158 | 0.56 | 3.1 | 2.1 | 8.7 | 56.2 | 19 | 2 | 1 | 0 | 13 | 54 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 1.77 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 97 | 48 | 0 | 0 | 0 | 0.00 | .075 | 0.24 | 1.9 | 0.3 | 9.6 | 28.2 | 6 | 0 | 0 | 0 | 1 | 30 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0.96 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 88 | 23 | 0 | 1 | 4 | 0.93 | .211 | 0.80 | 5.4 | 1.9 | 10.7 | 38.2 | 23 | 5 | 4 | 0 | 8 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.26 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 82 | 31 | 0 | 3 | 0 | 0.00 | .092 | 0.30 | 1.6 | 1.2 | 9.1 | 62.2 | 11 | 0 | 0 | 0 | 8 | 63 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.35 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 80 | 27 | 0 | 5 | 5 | 0.84 | .145 | 0.51 | 3.6 | 1.0 | 5.4 | 74.2 | 30 | 7 | 7 | 2 | 8 | 44 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.49 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 74 | 22 | 0 | 0 | 1 | 0.00 | .161 | 0.58 | 3.5 | 1.6 | 10.6 | 33.0 | 13 | 1 | 0 | 0 | 6 | 39 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.18 |
| SP | Overall, O.Overall, Orval >> | 28 | 1909 | R | 77 | 7 | 0 | 2 | 2 | 0.51 | .178 | 0.65 | 4.1 | 1.8 | 5.9 | 35.1 | 16 | 2 | 2 | 1 | 7 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.66 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 89 | 11 | 0 | 2 | 2 | 0.19 | .143 | 0.50 | 2.9 | 1.6 | 5.0 | 96.0 | 31 | 2 | 2 | 0 | 17 | 53 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.43 |