| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 99 | 34 | 34 | 10 | 7 | 0.39 | .146 | 0.50 | 3.4 | 1.1 | 8.5 | 323.2 | 123 | 14 | 14 | 1 | 39 | 305 | 17 | 0 | 0 | 9 | 34 | 4 | 3 | 1.55 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 98 | 34 | 34 | 4 | 5 | 0.37 | .128 | 0.44 | 2.9 | 1.0 | 7.8 | 319.1 | 103 | 13 | 13 | 1 | 37 | 277 | 6 | 0 | 0 | 2 | 34 | 1 | 2 | 1.66 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 92 | 34 | 33 | 7 | 5 | 0.29 | .120 | 0.40 | 2.8 | 0.8 | 5.8 | 250.1 | 78 | 8 | 8 | 0 | 22 | 162 | 1 | 0 | 0 | 1 | 32 | 2 | 3 | 1.99 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 92 | 35 | 33 | 5 | 7 | 0.47 | .140 | 0.49 | 3.5 | 0.9 | 8.8 | 289.0 | 111 | 16 | 15 | 0 | 30 | 283 | 3 | 0 | 0 | 1 | 33 | 0 | 2 | 1.35 |
| RP | Davis, W.Davis, Wade † >> | 29 | 2015 | R | 94 | 101 | 0 | 6 | 1 | 0.15 | .122 | 0.40 | 2.6 | 1.0 | 8.8 | 117.1 | 34 | 2 | 2 | 0 | 13 | 115 | 0 | 6 | 0 | 0 | 0 | 2 | 1 | 1.42 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 100 | 109 | 0 | 2 | 1 | 0.00 | .077 | 0.25 | 2.3 | 0.0 | 8.3 | 63.2 | 16 | 1 | 0 | 0 | 0 | 58 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1.16 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 92 | 77 | 0 | 7 | 4 | 0.32 | .105 | 0.35 | 2.5 | 0.6 | 7.3 | 113.1 | 32 | 4 | 4 | 0 | 8 | 92 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 1.58 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 86 | 61 | 0 | 5 | 4 | 0.26 | .138 | 0.47 | 3.4 | 0.9 | 7.7 | 102.1 | 38 | 5 | 3 | 0 | 10 | 87 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 1.62 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 47 | 0 | 4 | 4 | 0.54 | .156 | 0.55 | 3.0 | 2.0 | 8.8 | 83.0 | 28 | 5 | 5 | 1 | 18 | 81 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 1.86 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 85 | 12 | 1 | 2 | 6 | 0.44 | .136 | 0.46 | 3.1 | 1.1 | 7.5 | 101.1 | 35 | 7 | 5 | 1 | 12 | 84 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1.85 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 68 | 32 | 0 | 3 | 5 | 0.54 | .173 | 0.60 | 4.7 | 0.7 | 3.6 | 67.0 | 35 | 5 | 4 | 0 | 5 | 27 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.51 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 78 | 26 | 0 | 7 | 7 | 0.51 | .195 | 0.71 | 5.1 | 1.4 | 5.9 | 158.1 | 89 | 11 | 9 | 0 | 24 | 104 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 2.18 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 79 | 44 | 0 | 8 | 12 | 0.69 | .192 | 0.70 | 4.6 | 1.7 | 8.6 | 170.0 | 86 | 15 | 13 | 1 | 33 | 162 | 0 | 1 | 0 | 0 | 0 | 2 | 7 | 1.79 |