| SP | Hendricks, K.Hendricks, Kyle >> | 34 | 2016 | R | 98 | 18 | 18 | 8 | 7 | 3.11 | .252 | 0.99 | 7.3 | 1.7 | 6.3 | 121.2 | 98 | 42 | 42 | 14 | 23 | 85 | 4 | 0 | 0 | 1 | 12 | 2 | 4 | 3.72 |
| SP | Arrieta, J.Arrieta, Jake >> | 37 | 2015 | R | 94 | 18 | 18 | 3 | 4 | 3.11 | .298 | 1.26 | 8.8 | 2.6 | 6.3 | 118.2 | 116 | 43 | 41 | 10 | 34 | 82 | 1 | 0 | 0 | 0 | 14 | 1 | 4 | 3.60 |
| SP | Krukow, M.Krukow, Mike >> | 32 | 1978 | R | 78 | 18 | 18 | 6 | 5 | 5.15 | .324 | 1.40 | 9.5 | 3.2 | 4.8 | 71.2 | 75 | 41 | 41 | 14 | 25 | 38 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 5.68 |
| SP | Lester, J.Lester, Jon # >> | 40 | 2016 | L | 67 | 16 | 16 | 4 | 2 | 5.22 | .315 | 1.33 | 8.6 | 3.4 | 4.7 | 69.0 | 66 | 40 | 40 | 6 | 26 | 36 | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 4.35 |
| SP | Sanderson, S.Sanderson, Scott >> | 28 | 1984 | R | 48 | 15 | 14 | 7 | 3 | 4.28 | .309 | 1.31 | 9.4 | 2.4 | 4.9 | 61.0 | 64 | 32 | 29 | 6 | 16 | 33 | 0 | 0 | 0 | 0 | 4 | 2 | 3 | 4.08 |
| RP | Grimm, J.Grimm, Justin >> | 34 | 2015 | R | 98 | 56 | 0 | 7 | 1 | 2.86 | .270 | 1.11 | 5.2 | 4.8 | 10.3 | 69.1 | 40 | 22 | 22 | 3 | 37 | 79 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 2.88 |
| RP | Chapman, A.Chapman, Aroldis >> | 36 | 2016 | L | 96 | 48 | 0 | 5 | 1 | 3.19 | .291 | 1.21 | 6.6 | 4.3 | 8.6 | 48.0 | 35 | 19 | 17 | 6 | 23 | 46 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 4.21 |
| RP | Edwards, C.Edwards, Carl >> | 32 | 2016 | R | 95 | 48 | 0 | 0 | 1 | 3.54 | .282 | 1.18 | 6.5 | 4.3 | 9.5 | 40.2 | 29 | 16 | 16 | 4 | 19 | 42 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.63 |
| RP | Montgomery, M.Montgomery, Mike >> | 34 | 2016 | L | 85 | 49 | 0 | 2 | 0 | 4.07 | .263 | 1.07 | 7.9 | 1.9 | 6.6 | 48.2 | 42 | 23 | 22 | 7 | 10 | 35 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.06 |
| RP | Caudill, B.Caudill, Bill >> | 28 | 1980 | R | 79 | 29 | 0 | 3 | 1 | 1.81 | .234 | 0.92 | 5.9 | 2.5 | 5.3 | 44.2 | 29 | 11 | 9 | 4 | 12 | 26 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 3.82 |
| CL | Sutter, B.Sutter, Bruce >> | 31 | 1977 | R | 100 | 37 | 0 | 2 | 6 | 3.80 | .290 | 1.20 | 8.6 | 2.3 | 7.1 | 47.1 | 45 | 20 | 20 | 3 | 12 | 37 | 0 | 17 | 4 | 0 | 0 | 1 | 3 | 3.09 |