| SP | Arrieta, J.Arrieta, Jake † >> | 32 | 2015 | R | 100 | 34 | 34 | 15 | 9 | 2.94 | .261 | 1.04 | 6.7 | 2.7 | 7.4 | 226.2 | 169 | 79 | 74 | 16 | 67 | 186 | 4 | 0 | 0 | 3 | 24 | 4 | 6 | 3.22 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 29 | 2016 | R | 100 | 35 | 35 | 16 | 9 | 3.41 | .262 | 1.03 | 7.2 | 2.1 | 5.9 | 214.0 | 171 | 87 | 81 | 20 | 50 | 141 | 3 | 0 | 0 | 0 | 23 | 7 | 4 | 3.70 |
| SP | Lester, J.Lester, Jon # >> | 35 | 2016 | L | 93 | 33 | 33 | 12 | 8 | 4.36 | .307 | 1.31 | 8.6 | 3.2 | 6.6 | 196.0 | 187 | 100 | 95 | 21 | 69 | 143 | 0 | 0 | 0 | 0 | 19 | 5 | 4 | 4.07 |
| SP | Lackey, J.Lackey, John >> | 41 | 2016 | R | 88 | 32 | 32 | 13 | 5 | 4.20 | .309 | 1.32 | 9.4 | 2.5 | 6.0 | 145.2 | 151 | 69 | 68 | 14 | 41 | 96 | 0 | 0 | 0 | 0 | 11 | 3 | 1 | 3.84 |
| SP | Reuschel, R.Reuschel, Rick >> | 30 | 1977 | R | 68 | 28 | 28 | 6 | 7 | 3.73 | .285 | 1.15 | 7.8 | 2.6 | 6.2 | 147.1 | 128 | 64 | 61 | 15 | 42 | 101 | 0 | 0 | 0 | 0 | 13 | 6 | 4 | 3.93 |
| RP | Grimm, J.Grimm, Justin >> | 29 | 2015 | R | 99 | 86 | 0 | 5 | 6 | 4.06 | .326 | 1.39 | 8.2 | 4.3 | 9.3 | 93.0 | 85 | 46 | 42 | 7 | 44 | 96 | 0 | 0 | 1 | 0 | 0 | 6 | 5 | 3.53 |
| RP | Edwards, C.Edwards, Carl >> | 27 | 2016 | R | 99 | 69 | 0 | 9 | 3 | 2.85 | .252 | 1.01 | 5.5 | 3.6 | 8.6 | 82.0 | 50 | 26 | 26 | 6 | 33 | 78 | 0 | 2 | 0 | 0 | 0 | 0 | 7 | 3.26 |
| RP | Rondon, H.Rondon, Hector >> | 30 | 2015 | R | 90 | 52 | 0 | 2 | 0 | 1.26 | .242 | 0.94 | 5.8 | 2.7 | 7.1 | 57.1 | 37 | 8 | 8 | 1 | 17 | 45 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 2.60 |
| RP | Montgomery, M.Montgomery, Mike >> | 29 | 2016 | L | 84 | 86 | 0 | 5 | 4 | 3.03 | .258 | 1.01 | 5.5 | 3.6 | 4.4 | 89.0 | 54 | 30 | 30 | 3 | 36 | 44 | 0 | 2 | 2 | 0 | 0 | 3 | 8 | 3.76 |
| CL | Chapman, A.Chapman, Aroldis † >> | 31 | 2016 | L | 100 | 77 | 0 | 6 | 8 | 3.30 | .320 | 1.41 | 8.9 | 3.9 | 9.1 | 76.1 | 75 | 28 | 28 | 7 | 33 | 77 | 0 | 43 | 5 | 0 | 0 | 0 | 3 | 3.47 |
| SU | Sutter, B.Sutter, Bruce >> | 26 | 1977 | R | 100 | 70 | 0 | 1 | 1 | 2.59 | .261 | 1.05 | 7.1 | 2.3 | 8.5 | 87.0 | 69 | 26 | 25 | 8 | 22 | 82 | 0 | 10 | 5 | 0 | 0 | 1 | 5 | 3.10 |