| SP | Hendricks, K.Hendricks, Kyle >> | 31 | 2016 | R | 100 | 36 | 36 | 11 | 18 | 4.23 | .306 | 1.27 | 9.1 | 2.4 | 6.4 | 221.1 | 223 | 115 | 104 | 23 | 59 | 158 | 2 | 0 | 0 | 2 | 20 | 11 | 5 | 3.87 |
| SP | Arrieta, J.Arrieta, Jake >> | 34 | 2015 | R | 99 | 36 | 36 | 10 | 13 | 3.90 | .304 | 1.29 | 8.9 | 2.7 | 7.8 | 228.1 | 225 | 105 | 99 | 26 | 69 | 198 | 2 | 0 | 0 | 0 | 23 | 5 | 3 | 3.72 |
| SP | Lester, J.Lester, Jon # >> | 37 | 2016 | L | 81 | 35 | 35 | 2 | 18 | 6.26 | .340 | 1.53 | 10.1 | 3.8 | 5.8 | 136.2 | 152 | 97 | 95 | 21 | 57 | 87 | 0 | 0 | 0 | 0 | 5 | 2 | 5 | 5.03 |
| SP | Krukow, M.Krukow, Mike # >> | 29 | 1978 | R | 75 | 33 | 33 | 5 | 7 | 4.91 | .314 | 1.37 | 9.4 | 2.9 | 5.1 | 141.0 | 148 | 83 | 77 | 20 | 45 | 80 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 4.69 |
| SP | Lackey, J.Lackey, John # >> | 43 | 2016 | R | 67 | 35 | 27 | 8 | 8 | 4.80 | .320 | 1.41 | 9.4 | 3.3 | 6.4 | 138.2 | 144 | 75 | 74 | 25 | 51 | 98 | 0 | 2 | 0 | 0 | 6 | 1 | 2 | 5.07 |
| RP | Grimm, J.Grimm, Justin # >> | 31 | 2015 | R | 100 | 102 | 0 | 11 | 4 | 4.83 | .299 | 1.22 | 7.1 | 3.9 | 8.8 | 138.0 | 109 | 77 | 74 | 14 | 60 | 135 | 0 | 0 | 2 | 0 | 0 | 8 | 17 | 3.84 |
| RP | Chapman, A.Chapman, Aroldis >> | 33 | 2016 | L | 100 | 113 | 0 | 4 | 2 | 2.96 | .247 | 0.95 | 5.2 | 3.4 | 10.3 | 115.2 | 66 | 42 | 38 | 8 | 44 | 132 | 0 | 7 | 4 | 0 | 0 | 4 | 8 | 2.86 |
| RP | Edwards, C.Edwards, Carl >> | 29 | 2016 | R | 100 | 106 | 0 | 5 | 4 | 2.86 | .276 | 1.12 | 6.0 | 4.1 | 10.7 | 100.2 | 67 | 33 | 32 | 8 | 46 | 119 | 0 | 5 | 0 | 0 | 0 | 2 | 8 | 3.10 |
| RP | Sutter, B.Sutter, Bruce >> | 28 | 1977 | R | 98 | 79 | 0 | 5 | 5 | 2.07 | .245 | 0.94 | 6.2 | 2.4 | 8.4 | 95.2 | 65 | 26 | 22 | 8 | 25 | 89 | 0 | 13 | 8 | 0 | 0 | 3 | 4 | 3.11 |
| RP | Rondon, H.Rondon, Hector >> | 32 | 2015 | R | 87 | 52 | 0 | 7 | 5 | 4.35 | .291 | 1.20 | 8.1 | 2.7 | 8.6 | 60.0 | 54 | 32 | 29 | 8 | 18 | 57 | 0 | 4 | 3 | 0 | 0 | 2 | 3 | 3.83 |
| RP | Montgomery, M.Montgomery, Mike >> | 31 | 2016 | L | 84 | 97 | 0 | 9 | 3 | 4.05 | .257 | 1.01 | 6.2 | 2.9 | 5.5 | 93.1 | 64 | 43 | 42 | 12 | 30 | 57 | 0 | 8 | 4 | 0 | 0 | 3 | 6 | 4.52 |