| SP | Jimenez, U.Jimenez, Ubaldo >> | 26 | 2010 | R | 63 | 30 | 30 | 7 | 11 | 4.49 | .305 | 1.30 | 8.6 | 3.2 | 6.4 | 180.1 | 172 | 90 | 90 | 14 | 63 | 127 | 2 | 0 | 0 | 1 | 15 | 2 | 6 | 3.68 |
| SP | Marquez, G.Marquez, German >> | 23 | 2018 | R | 52 | 30 | 30 | 10 | 10 | 5.41 | .337 | 1.50 | 10.1 | 3.4 | 7.8 | 153.0 | 171 | 96 | 92 | 14 | 58 | 133 | 0 | 0 | 0 | 0 | 11 | 4 | 4 | 3.67 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 45 | 29 | 29 | 6 | 11 | 5.24 | .318 | 1.37 | 9.4 | 3.0 | 5.6 | 137.1 | 143 | 82 | 80 | 13 | 45 | 85 | 0 | 0 | 0 | 0 | 8 | 4 | 1 | 4.07 |
| SP | Chacin, J.Chacin, Jhoulys # >> | 22 | 2010 | R | 47 | 29 | 27 | 8 | 11 | 4.39 | .301 | 1.27 | 7.6 | 3.8 | 7.1 | 133.1 | 113 | 68 | 65 | 8 | 56 | 105 | 0 | 0 | 0 | 0 | 10 | 3 | 4 | 3.53 |
| RP | Ottavino, A.Ottavino, Adam † >> | 32 | 2018 | R | 65 | 77 | 0 | 9 | 5 | 2.67 | .275 | 1.12 | 6.4 | 3.7 | 10.3 | 108.0 | 77 | 36 | 32 | 5 | 44 | 124 | 0 | 4 | 5 | 0 | 0 | 2 | 4 | 2.58 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 60 | 71 | 0 | 5 | 4 | 3.55 | .257 | 1.04 | 7.7 | 1.7 | 7.6 | 96.1 | 82 | 38 | 38 | 15 | 18 | 81 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 3.91 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 57 | 61 | 0 | 1 | 1 | 2.76 | .281 | 1.14 | 6.0 | 4.4 | 7.5 | 71.2 | 47 | 22 | 22 | 4 | 35 | 59 | 0 | 9 | 1 | 0 | 0 | 2 | 5 | 3.63 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 50 | 39 | 0 | 4 | 1 | 4.65 | .317 | 1.37 | 10.1 | 2.3 | 8.3 | 50.1 | 56 | 26 | 26 | 5 | 13 | 46 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.30 |
| SP | De La Rosa, J.De La Rosa, Jorge # >> | 29 | 2010 | L | 39 | 28 | 1 | 8 | 3 | 4.24 | .293 | 1.24 | 7.7 | 3.5 | 5.9 | 129.1 | 110 | 61 | 61 | 15 | 50 | 85 | 0 | 0 | 0 | 0 | 0 | 1 | 8 | 4.38 |