| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 69 | 4 | 4 | 1 | 2 | 3.91 | .309 | 1.30 | 8.3 | 3.6 | 8.3 | 25.1 | 23 | 11 | 11 | 2 | 10 | 23 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.52 |
| SP | Garcia, F.Garcia, Freddy # >> | 26 | 2001 | R | 61 | 4 | 4 | 0 | 3 | 6.04 | .356 | 1.66 | 12.6 | 2.5 | 5.8 | 25.1 | 35 | 19 | 17 | 8 | 7 | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6.72 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 49 | 3 | 3 | 3 | 0 | 0.90 | .302 | 1.20 | 7.7 | 3.2 | 7.7 | 20.0 | 17 | 2 | 2 | 1 | 7 | 17 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 3.30 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 48 | 4 | 4 | 0 | 2 | 9.50 | .443 | 2.28 | 14.5 | 6.0 | 4.0 | 18.0 | 29 | 21 | 19 | 2 | 12 | 8 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 5.89 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 91 | 12 | 0 | 1 | 0 | 1.62 | .286 | 1.14 | 8.4 | 2.3 | 7.9 | 16.2 | 15 | 3 | 3 | 1 | 4 | 14 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.00 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 46 | 9 | 0 | 0 | 1 | 8.31 | .422 | 2.08 | 9.0 | 11.3 | 5.6 | 8.2 | 8 | 8 | 8 | 0 | 10 | 5 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.88 |
| RP | Shields, S.Shields, Scot >> | 30 | 2005 | R | 30 | 8 | 0 | 1 | 1 | 6.10 | .311 | 1.26 | 9.0 | 2.7 | 5.4 | 10.1 | 10 | 8 | 7 | 2 | 3 | 6 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.60 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 1 | 1 | 0 | 0 | 8.31 | .409 | 2.08 | 9.0 | 11.3 | 4.5 | 4.1 | 4 | 4 | 4 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9.00 |
| SP | Colon, B.Colon, Bartolo >> | 32 | 2005 | R | 22 | 8 | 0 | 0 | 0 | 4.32 | .324 | 1.44 | 9.0 | 4.5 | 5.6 | 8.1 | 8 | 4 | 4 | 0 | 4 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.25 |