| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 15 | 15 | 4 | 5 | 4.26 | .313 | 1.34 | 8.0 | 4.2 | 8.6 | 88.2 | 78 | 45 | 42 | 15 | 41 | 84 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 4.77 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 15 | 15 | 1 | 3 | 4.72 | .346 | 1.57 | 10.2 | 4.0 | 7.5 | 61.0 | 69 | 37 | 32 | 6 | 27 | 51 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.98 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 16 | 15 | 8 | 5 | 4.27 | .303 | 1.28 | 8.6 | 3.0 | 7.6 | 90.2 | 86 | 45 | 43 | 13 | 30 | 76 | 1 | 0 | 0 | 1 | 9 | 2 | 0 | 4.26 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 16 | 14 | 6 | 2 | 6.26 | .342 | 1.50 | 11.1 | 2.4 | 5.8 | 82.0 | 101 | 61 | 57 | 21 | 22 | 53 | 0 | 0 | 1 | 0 | 4 | 5 | 1 | 6.02 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 39 | 0 | 3 | 2 | 3.88 | .319 | 1.41 | 7.6 | 5.1 | 10.0 | 53.1 | 45 | 27 | 23 | 6 | 30 | 59 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 3.94 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 36 | 0 | 3 | 4 | 3.75 | .260 | 1.01 | 6.8 | 2.3 | 10.3 | 50.1 | 38 | 22 | 21 | 11 | 13 | 57 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.48 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 52 | 37 | 0 | 4 | 3 | 3.02 | .287 | 1.19 | 7.8 | 3.1 | 10.0 | 44.2 | 38 | 15 | 15 | 6 | 15 | 49 | 0 | 1 | 4 | 0 | 0 | 1 | 1 | 3.64 |
| CL | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 34 | 0 | 4 | 4 | 3.06 | .248 | 0.99 | 6.2 | 2.8 | 10.0 | 35.1 | 24 | 13 | 12 | 4 | 11 | 39 | 0 | 14 | 2 | 0 | 0 | 0 | 2 | 3.20 |
| SU | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 85 | 33 | 0 | 2 | 0 | 2.03 | .264 | 1.05 | 5.6 | 3.8 | 9.5 | 40.0 | 25 | 11 | 9 | 3 | 17 | 42 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 3.23 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 27 | 0 | 1 | 0 | 3.13 | .258 | 1.04 | 7.5 | 2.0 | 8.7 | 31.2 | 26 | 12 | 11 | 4 | 7 | 30 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.42 |