| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 24 | 24 | 10 | 8 | 3.92 | .299 | 1.26 | 7.8 | 3.6 | 9.6 | 165.1 | 143 | 74 | 72 | 21 | 66 | 176 | 4 | 0 | 0 | 1 | 15 | 3 | 4 | 3.78 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 86 | 23 | 23 | 11 | 7 | 3.59 | .294 | 1.24 | 8.9 | 2.3 | 5.8 | 175.2 | 173 | 74 | 70 | 15 | 45 | 113 | 6 | 0 | 0 | 1 | 14 | 1 | 2 | 3.61 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 23 | 23 | 7 | 5 | 5.21 | .342 | 1.52 | 10.6 | 3.1 | 5.4 | 133.0 | 156 | 80 | 77 | 21 | 46 | 80 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 5.00 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 23 | 23 | 10 | 6 | 5.71 | .358 | 1.64 | 10.9 | 3.9 | 5.4 | 149.2 | 181 | 99 | 95 | 29 | 65 | 89 | 3 | 0 | 0 | 0 | 7 | 4 | 2 | 5.72 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 33 | 0 | 5 | 5 | 2.35 | .268 | 1.10 | 7.6 | 2.4 | 8.8 | 38.1 | 32 | 13 | 10 | 4 | 10 | 37 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.21 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 73 | 17 | 0 | 1 | 2 | 3.86 | .259 | 1.05 | 7.3 | 2.1 | 7.7 | 21.0 | 17 | 9 | 9 | 4 | 5 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.48 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 13 | 0 | 1 | 2 | 8.64 | .405 | 2.04 | 19.1 | 0.0 | 7.9 | 8.1 | 17 | 8 | 8 | 2 | 0 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 13 | 0 | 0 | 0 | 2.84 | .240 | 0.95 | 6.0 | 3.0 | 12.0 | 12.2 | 8 | 4 | 4 | 1 | 4 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.42 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 15 | 0 | 2 | 4 | 5.16 | .330 | 1.46 | 10.6 | 2.6 | 7.8 | 66.1 | 78 | 40 | 38 | 16 | 19 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.33 |