| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 99 | 26 | 26 | 14 | 6 | 4.12 | .311 | 1.33 | 8.2 | 3.9 | 9.0 | 181.1 | 164 | 89 | 83 | 25 | 78 | 180 | 4 | 0 | 0 | 3 | 14 | 4 | 4 | 4.17 |
| SP | Wakefield, T.Wakefield, Tim # >> | 36 | 2002 | R | 86 | 24 | 21 | 3 | 6 | 4.55 | .311 | 1.31 | 8.6 | 3.2 | 6.3 | 87.0 | 83 | 46 | 44 | 12 | 31 | 61 | 0 | 0 | 0 | 0 | 1 | 4 | 3 | 4.60 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 77 | 26 | 26 | 8 | 10 | 4.88 | .327 | 1.42 | 10.0 | 2.7 | 6.4 | 166.0 | 185 | 94 | 90 | 32 | 50 | 118 | 1 | 0 | 0 | 0 | 13 | 7 | 0 | 5.11 |
| SP | Loaiza, E.Loaiza, Esteban # >> | 32 | 2003 | R | 58 | 25 | 24 | 9 | 4 | 4.98 | .321 | 1.38 | 9.2 | 3.2 | 6.6 | 159.0 | 163 | 91 | 88 | 22 | 56 | 116 | 1 | 0 | 1 | 0 | 9 | 7 | 2 | 4.53 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 26 | 17 | 10 | 9 | 5.47 | .340 | 1.52 | 10.2 | 3.5 | 6.9 | 125.0 | 142 | 78 | 76 | 24 | 48 | 96 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 5.18 |
| CL | Rincon, J.Rincon, Juan † >> | 25 | 2004 | R | 59 | 52 | 0 | 2 | 6 | 2.68 | .234 | 0.89 | 5.9 | 2.2 | 9.9 | 50.1 | 33 | 15 | 15 | 9 | 12 | 55 | 0 | 25 | 5 | 0 | 0 | 1 | 1 | 3.92 |
| SU | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 63 | 0 | 4 | 1 | 3.77 | .322 | 1.40 | 8.1 | 4.6 | 11.7 | 71.2 | 64 | 30 | 30 | 5 | 36 | 92 | 0 | 2 | 2 | 0 | 0 | 2 | 5 | 2.93 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 33 | 0 | 3 | 2 | 5.34 | .319 | 1.41 | 9.8 | 2.8 | 7.3 | 32.0 | 35 | 21 | 19 | 3 | 10 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.53 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 36 | 0 | 3 | 3 | 5.59 | .376 | 1.76 | 9.5 | 6.6 | 7.3 | 38.2 | 40 | 24 | 24 | 5 | 28 | 31 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.45 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 31 | 0 | 3 | 1 | 5.97 | .336 | 1.52 | 11.3 | 2.6 | 10.5 | 31.2 | 39 | 21 | 21 | 9 | 9 | 36 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 5.32 |
| SP | Maine, J.Maine, John # >> | 25 | 2006 | R | 69 | 26 | 13 | 7 | 6 | 6.37 | .349 | 1.58 | 10.1 | 4.2 | 6.5 | 117.1 | 131 | 85 | 83 | 26 | 54 | 84 | 0 | 0 | 0 | 0 | 3 | 4 | 4 | 5.94 |