| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 29 | 29 | 2 | 4 | 3.59 | .272 | 1.11 | 7.2 | 2.9 | 7.2 | 123.0 | 98 | 51 | 49 | 16 | 39 | 99 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 4.06 |
| SP | Schmidt, J.Schmidt, Jason # $ >> | 30 | 2003 | R | 99 | 29 | 29 | 14 | 7 | 4.06 | .312 | 1.33 | 8.8 | 3.3 | 8.6 | 201.2 | 196 | 91 | 91 | 27 | 73 | 191 | 3 | 0 | 0 | 1 | 16 | 5 | 2 | 4.01 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 67 | 28 | 28 | 10 | 8 | 4.91 | .336 | 1.50 | 10.0 | 3.5 | 6.4 | 165.0 | 183 | 93 | 90 | 30 | 64 | 118 | 0 | 0 | 0 | 0 | 11 | 4 | 0 | 5.17 |
| SP | Williams, W.Williams, Woody # >> | 36 | 2002 | R | 79 | 29 | 29 | 11 | 14 | 5.04 | .320 | 1.40 | 9.6 | 3.1 | 6.9 | 176.2 | 187 | 105 | 99 | 30 | 60 | 134 | 0 | 0 | 0 | 0 | 15 | 2 | 5 | 4.75 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 27 | 23 | 7 | 9 | 5.41 | .332 | 1.47 | 10.1 | 3.3 | 8.3 | 154.2 | 172 | 102 | 93 | 26 | 56 | 142 | 2 | 0 | 0 | 0 | 8 | 3 | 5 | 4.50 |
| CL | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 55 | 0 | 2 | 9 | 2.62 | .270 | 1.07 | 5.4 | 4.3 | 10.3 | 55.0 | 33 | 16 | 16 | 10 | 26 | 63 | 0 | 31 | 3 | 0 | 0 | 2 | 1 | 4.60 |
| SU | Springer, R.Springer, Russ >> | 39 | 2007 | R | 79 | 61 | 0 | 6 | 3 | 3.13 | .279 | 1.12 | 6.3 | 3.9 | 9.6 | 77.2 | 54 | 28 | 27 | 6 | 33 | 82 | 0 | 0 | 3 | 0 | 0 | 3 | 1 | 3.29 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 47 | 0 | 1 | 4 | 3.15 | .231 | 0.88 | 5.7 | 2.3 | 10.7 | 54.1 | 34 | 19 | 19 | 5 | 14 | 64 | 0 | 6 | 1 | 0 | 0 | 1 | 2 | 2.67 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 59 | 46 | 0 | 2 | 2 | 3.80 | .278 | 1.13 | 6.4 | 3.8 | 9.2 | 45.0 | 32 | 22 | 19 | 8 | 19 | 46 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.60 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 38 | 0 | 4 | 1 | 4.19 | .310 | 1.29 | 8.5 | 3.3 | 10.4 | 38.2 | 36 | 18 | 18 | 4 | 14 | 44 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.32 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 33 | 0 | 2 | 1 | 4.35 | .350 | 1.55 | 10.5 | 3.5 | 8.1 | 31.0 | 36 | 15 | 15 | 3 | 12 | 28 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.81 |
| SP | Loaiza, E.Loaiza, Esteban # $ >> | 32 | 2003 | R | 60 | 29 | 6 | 12 | 6 | 6.33 | .346 | 1.58 | 11.1 | 3.1 | 7.2 | 118.0 | 145 | 84 | 83 | 25 | 41 | 94 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 5.23 |