| SP | Wakefield, T.Wakefield, Tim $ >> | 36 | 2002 | R | 86 | 15 | 14 | 1 | 3 | 3.43 | .300 | 1.27 | 7.7 | 3.7 | 6.6 | 63.0 | 54 | 28 | 24 | 6 | 26 | 46 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.06 |
| SP | Bedard, E.Bedard, Erik # >> | 28 | 2007 | L | 80 | 14 | 13 | 5 | 4 | 3.89 | .322 | 1.40 | 8.5 | 4.2 | 9.4 | 83.1 | 78 | 37 | 36 | 7 | 39 | 87 | 1 | 0 | 0 | 0 | 8 | 2 | 0 | 3.48 |
| SP | Young, C.Young, Chris # >> | 28 | 2007 | R | 82 | 15 | 14 | 5 | 2 | 4.23 | .316 | 1.36 | 8.2 | 4.2 | 8.2 | 78.2 | 71 | 43 | 37 | 9 | 36 | 71 | 0 | 0 | 0 | 0 | 7 | 2 | 6 | 4.14 |
| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 92 | 15 | 12 | 4 | 3 | 5.40 | .329 | 1.45 | 11.3 | 1.8 | 10.7 | 88.1 | 110 | 54 | 53 | 14 | 18 | 105 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 3.36 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 30 | 0 | 4 | 2 | 3.44 | .306 | 1.29 | 10.1 | 1.6 | 8.2 | 34.0 | 38 | 13 | 13 | 4 | 6 | 31 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.32 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 69 | 23 | 0 | 1 | 3 | 4.44 | .318 | 1.40 | 9.0 | 3.8 | 5.6 | 24.1 | 24 | 14 | 12 | 6 | 10 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.25 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 32 | 0 | 1 | 1 | 4.50 | .315 | 1.32 | 7.1 | 4.8 | 10.3 | 34.0 | 27 | 17 | 17 | 7 | 18 | 39 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 5.15 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 18 | 0 | 1 | 1 | 4.76 | .346 | 1.47 | 6.9 | 6.4 | 6.9 | 17.0 | 13 | 9 | 9 | 2 | 12 | 13 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 5.47 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 25 | 0 | 2 | 3 | 4.78 | .273 | 1.09 | 6.5 | 3.4 | 8.4 | 32.0 | 23 | 17 | 17 | 3 | 12 | 30 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.56 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 12 | 6 | 3 | 5 | 5.93 | .341 | 1.55 | 10.5 | 3.7 | 5.3 | 54.2 | 63 | 41 | 36 | 13 | 22 | 32 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 6.17 |