| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 34 | 34 | 7 | 13 | 4.48 | .330 | 1.45 | 9.8 | 3.3 | 6.6 | 211.0 | 230 | 109 | 105 | 24 | 77 | 154 | 0 | 0 | 0 | 0 | 19 | 5 | 4 | 4.18 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 31 | 31 | 3 | 11 | 4.82 | .326 | 1.42 | 8.0 | 4.8 | 6.4 | 125.0 | 111 | 67 | 67 | 13 | 66 | 89 | 0 | 0 | 0 | 0 | 1 | 4 | 8 | 4.61 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 33 | 33 | 10 | 11 | 4.98 | .331 | 1.47 | 9.2 | 4.1 | 6.5 | 197.0 | 201 | 109 | 109 | 35 | 89 | 142 | 1 | 0 | 0 | 0 | 14 | 3 | 5 | 5.27 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 68 | 32 | 30 | 12 | 6 | 5.13 | .338 | 1.45 | 10.7 | 2.3 | 7.8 | 184.1 | 219 | 114 | 105 | 32 | 48 | 159 | 0 | 0 | 0 | 0 | 14 | 15 | 3 | 4.56 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 58 | 31 | 31 | 8 | 14 | 5.84 | .333 | 1.46 | 10.2 | 2.9 | 7.6 | 188.0 | 214 | 126 | 122 | 46 | 61 | 158 | 2 | 0 | 0 | 0 | 11 | 7 | 5 | 5.59 |
| CL | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 86 | 57 | 0 | 5 | 3 | 2.15 | .274 | 1.12 | 6.0 | 4.0 | 9.3 | 67.0 | 45 | 16 | 16 | 5 | 30 | 69 | 0 | 25 | 6 | 0 | 0 | 1 | 1 | 3.30 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 59 | 0 | 4 | 3 | 3.21 | .266 | 1.07 | 7.1 | 2.7 | 10.5 | 61.2 | 48 | 23 | 22 | 3 | 18 | 71 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 2.25 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 68 | 58 | 0 | 7 | 5 | 4.13 | .331 | 1.45 | 9.7 | 3.5 | 6.4 | 65.1 | 70 | 40 | 30 | 7 | 25 | 46 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 4.23 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 77 | 0 | 3 | 4 | 4.46 | .297 | 1.27 | 8.5 | 3.1 | 10.5 | 82.2 | 77 | 41 | 41 | 13 | 28 | 96 | 0 | 2 | 4 | 0 | 0 | 0 | 6 | 3.74 |
| SP | Hernandez, F.Hernandez, Felix # >> | 19 | 2005 | R | 96 | 31 | 3 | 7 | 7 | 6.96 | .371 | 1.73 | 12.1 | 3.6 | 6.4 | 129.1 | 173 | 100 | 100 | 23 | 51 | 92 | 0 | 0 | 0 | 0 | 1 | 5 | 3 | 5.19 |