| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 23 | 23 | 7 | 14 | 4.43 | .301 | 1.24 | 8.2 | 3.0 | 8.8 | 142.1 | 129 | 71 | 70 | 22 | 48 | 139 | 5 | 0 | 0 | 1 | 12 | 7 | 4 | 4.22 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 76 | 22 | 22 | 6 | 6 | 5.13 | .324 | 1.40 | 10.1 | 2.6 | 9.9 | 126.1 | 141 | 74 | 72 | 17 | 36 | 138 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 3.54 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 80 | 0 | 4 | 3 | 2.88 | .290 | 1.20 | 7.4 | 3.5 | 8.9 | 93.2 | 76 | 32 | 30 | 10 | 36 | 92 | 0 | 4 | 0 | 0 | 0 | 3 | 4 | 3.68 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 72 | 0 | 6 | 2 | 3.96 | .317 | 1.37 | 8.3 | 4.1 | 6.5 | 84.0 | 77 | 39 | 37 | 8 | 38 | 61 | 0 | 5 | 6 | 0 | 0 | 2 | 2 | 4.21 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 77 | 0 | 1 | 10 | 5.33 | .328 | 1.42 | 10.4 | 2.5 | 11.3 | 79.1 | 91 | 48 | 47 | 12 | 22 | 99 | 0 | 6 | 6 | 0 | 0 | 3 | 6 | 3.42 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 64 | 0 | 6 | 0 | 5.33 | .326 | 1.41 | 7.6 | 5.1 | 6.6 | 79.1 | 67 | 50 | 47 | 15 | 45 | 58 | 0 | 5 | 3 | 0 | 0 | 3 | 0 | 5.82 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 54 | 51 | 0 | 5 | 4 | 5.52 | .344 | 1.51 | 9.6 | 4.1 | 10.2 | 60.1 | 64 | 39 | 37 | 9 | 27 | 68 | 0 | 4 | 4 | 0 | 0 | 4 | 2 | 4.23 |