| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 35 | 35 | 13 | 12 | 4.03 | .311 | 1.32 | 7.9 | 4.0 | 10.7 | 230.0 | 202 | 107 | 103 | 27 | 102 | 274 | 1 | 0 | 0 | 1 | 18 | 8 | 8 | 3.58 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 87 | 34 | 34 | 14 | 13 | 4.25 | .298 | 1.25 | 9.6 | 1.7 | 6.0 | 241.1 | 256 | 117 | 114 | 38 | 45 | 160 | 5 | 0 | 0 | 2 | 16 | 6 | 6 | 4.36 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 33 | 32 | 10 | 11 | 4.36 | .332 | 1.45 | 8.8 | 4.3 | 7.1 | 183.2 | 178 | 99 | 89 | 25 | 88 | 144 | 0 | 0 | 0 | 0 | 19 | 8 | 7 | 4.78 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 31 | 31 | 14 | 9 | 4.97 | .330 | 1.44 | 9.2 | 3.8 | 6.6 | 184.2 | 189 | 108 | 102 | 25 | 77 | 134 | 0 | 0 | 0 | 0 | 13 | 7 | 2 | 4.68 |
| CL | Soria, J.Soria, Joakim † >> | 24 | 2008 | R | 88 | 68 | 0 | 2 | 9 | 2.74 | .289 | 1.19 | 7.8 | 3.0 | 7.2 | 65.2 | 56 | 22 | 20 | 10 | 22 | 52 | 0 | 44 | 4 | 0 | 0 | 2 | 1 | 4.51 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 72 | 0 | 3 | 4 | 3.36 | .293 | 1.24 | 7.7 | 3.6 | 9.9 | 80.1 | 68 | 30 | 30 | 11 | 32 | 88 | 0 | 3 | 4 | 0 | 0 | 0 | 7 | 3.79 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 23 | 0 | 2 | 0 | 1.61 | .247 | 0.99 | 6.5 | 2.5 | 11.5 | 22.1 | 16 | 4 | 4 | 1 | 6 | 28 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.86 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 18 | 0 | 1 | 0 | 2.04 | .274 | 1.13 | 6.9 | 3.7 | 9.0 | 17.2 | 13 | 4 | 4 | 3 | 7 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.53 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 20 | 0 | 1 | 0 | 2.28 | .194 | 0.65 | 4.0 | 2.0 | 8.3 | 27.2 | 12 | 8 | 7 | 3 | 6 | 25 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.48 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 61 | 18 | 1 | 3 | 0 | 4.38 | .301 | 1.28 | 8.5 | 3.1 | 7.4 | 88.1 | 83 | 45 | 43 | 17 | 30 | 72 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 4.93 |