| SP | Hernandez, F.Hernandez, Felix † >> | 19 | 2005 | R | 96 | 23 | 23 | 10 | 8 | 3.88 | .285 | 1.20 | 7.3 | 3.5 | 7.9 | 155.1 | 126 | 76 | 67 | 25 | 60 | 136 | 1 | 0 | 0 | 0 | 14 | 0 | 0 | 4.50 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 87 | 22 | 22 | 7 | 6 | 5.04 | .333 | 1.44 | 9.8 | 3.3 | 9.3 | 130.1 | 141 | 73 | 73 | 19 | 47 | 134 | 4 | 0 | 0 | 1 | 9 | 7 | 1 | 4.08 |
| SP | Williams, W.Williams, Woody # >> | 36 | 2002 | R | 78 | 22 | 22 | 11 | 5 | 4.42 | .302 | 1.27 | 9.2 | 2.2 | 7.5 | 134.1 | 137 | 72 | 66 | 23 | 33 | 112 | 1 | 0 | 0 | 1 | 12 | 4 | 1 | 4.39 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 22 | 22 | 9 | 10 | 6.02 | .332 | 1.46 | 10.2 | 3.0 | 8.1 | 125.2 | 142 | 86 | 84 | 24 | 41 | 112 | 2 | 0 | 0 | 0 | 10 | 4 | 2 | 4.78 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 59 | 22 | 21 | 7 | 6 | 5.75 | .350 | 1.61 | 10.5 | 4.1 | 6.6 | 128.1 | 149 | 90 | 82 | 25 | 58 | 94 | 3 | 0 | 0 | 0 | 9 | 0 | 2 | 5.43 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 49 | 0 | 4 | 4 | 2.85 | .289 | 1.22 | 8.7 | 2.3 | 9.2 | 60.0 | 58 | 22 | 19 | 4 | 15 | 61 | 0 | 25 | 4 | 0 | 0 | 0 | 2 | 2.58 |
| SU | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 86 | 45 | 0 | 1 | 2 | 6.11 | .325 | 1.42 | 6.8 | 6.2 | 11.8 | 45.2 | 34 | 32 | 31 | 8 | 31 | 59 | 0 | 2 | 5 | 0 | 0 | 1 | 1 | 4.82 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 34 | 0 | 1 | 4 | 5.54 | .368 | 1.72 | 10.2 | 5.3 | 9.0 | 39.0 | 44 | 24 | 24 | 5 | 23 | 39 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 4.51 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 38 | 0 | 2 | 2 | 4.43 | .306 | 1.32 | 7.8 | 4.3 | 10.6 | 44.2 | 38 | 22 | 22 | 4 | 21 | 52 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.25 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 24 | 0 | 3 | 0 | 4.34 | .326 | 1.38 | 10.6 | 1.9 | 9.3 | 29.0 | 34 | 14 | 14 | 4 | 6 | 30 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.55 |