| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 7 | 7 | 3 | 1 | 5.89 | .325 | 1.42 | 9.3 | 3.8 | 10.8 | 36.2 | 37 | 24 | 24 | 5 | 15 | 43 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 3.75 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 86 | 7 | 7 | 3 | 2 | 5.01 | .301 | 1.27 | 9.7 | 1.8 | 6.8 | 50.1 | 54 | 28 | 28 | 8 | 10 | 38 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 4.22 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 6 | 5 | 3 | 0 | 2.81 | .319 | 1.34 | 8.2 | 3.9 | 8.2 | 32.0 | 29 | 12 | 10 | 5 | 14 | 29 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.72 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 6 | 6 | 3 | 2 | 5.00 | .285 | 1.14 | 7.5 | 2.8 | 5.3 | 36.0 | 30 | 20 | 20 | 7 | 11 | 21 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 5.44 |
| CL | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 17 | 0 | 1 | 1 | 1.06 | .261 | 1.06 | 7.9 | 1.6 | 4.8 | 17.0 | 15 | 2 | 2 | 1 | 3 | 9 | 0 | 12 | 1 | 0 | 0 | 0 | 0 | 3.24 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 16 | 0 | 2 | 0 | 3.18 | .292 | 1.24 | 9.0 | 2.1 | 10.6 | 17.0 | 17 | 6 | 6 | 4 | 4 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 4 | 0 | 1 | 0 | 4.50 | .250 | 1.00 | 9.0 | 0.0 | 9.0 | 4.0 | 4 | 2 | 2 | 1 | 0 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.25 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 7 | 0 | 0 | 0 | 2.16 | .194 | 0.72 | 3.4 | 3.4 | 10.1 | 8.1 | 3 | 2 | 2 | 0 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.88 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 59 | 4 | 1 | 1 | 0 | 7.36 | .368 | 1.69 | 11.5 | 4.0 | 5.0 | 18.1 | 23 | 15 | 15 | 4 | 8 | 10 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 6.28 |