| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 23 | 23 | 9 | 9 | 5.38 | .310 | 1.31 | 8.6 | 3.2 | 10.0 | 144.0 | 137 | 87 | 86 | 17 | 51 | 160 | 1 | 0 | 0 | 0 | 11 | 6 | 6 | 3.50 |
| SP | Halladay, R.Halladay, Roy † # $ >> | 28 | 2005 | R | 86 | 22 | 22 | 12 | 7 | 3.27 | .258 | 1.03 | 7.7 | 1.6 | 6.8 | 165.0 | 141 | 62 | 60 | 19 | 29 | 124 | 4 | 0 | 0 | 2 | 14 | 2 | 1 | 3.56 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 22 | 22 | 8 | 4 | 5.49 | .344 | 1.50 | 10.6 | 3.0 | 7.4 | 116.1 | 136 | 76 | 71 | 22 | 39 | 95 | 0 | 0 | 0 | 0 | 8 | 8 | 2 | 5.04 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 21 | 21 | 8 | 5 | 4.99 | .316 | 1.35 | 8.8 | 3.5 | 5.2 | 122.2 | 119 | 69 | 68 | 17 | 47 | 70 | 1 | 0 | 0 | 0 | 11 | 4 | 1 | 4.92 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 21 | 21 | 7 | 7 | 6.30 | .354 | 1.60 | 10.9 | 3.6 | 6.3 | 114.1 | 138 | 82 | 80 | 18 | 45 | 80 | 0 | 0 | 0 | 0 | 9 | 5 | 11 | 4.96 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 57 | 0 | 8 | 2 | 3.01 | .284 | 1.19 | 8.8 | 2.1 | 8.4 | 74.2 | 72 | 27 | 25 | 10 | 17 | 69 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 43 | 0 | 2 | 1 | 2.63 | .290 | 1.21 | 5.8 | 5.1 | 6.9 | 51.1 | 33 | 15 | 15 | 3 | 29 | 39 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 4.00 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 39 | 0 | 5 | 4 | 3.93 | .214 | 0.79 | 5.4 | 1.8 | 7.6 | 50.1 | 30 | 22 | 22 | 8 | 10 | 42 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.06 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 27 | 0 | 0 | 1 | 5.91 | .377 | 1.81 | 12.1 | 4.2 | 8.2 | 32.0 | 43 | 24 | 21 | 8 | 15 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.84 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 26 | 0 | 1 | 1 | 4.81 | .354 | 1.64 | 9.4 | 5.6 | 9.8 | 24.1 | 25 | 14 | 13 | 5 | 15 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.42 |
| CL | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 100 | 46 | 0 | 1 | 4 | 3.49 | .303 | 1.31 | 7.9 | 3.9 | 9.0 | 49.0 | 43 | 21 | 19 | 10 | 21 | 49 | 0 | 25 | 2 | 0 | 0 | 0 | 0 | 4.94 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 38 | 0 | 2 | 1 | 7.64 | .361 | 1.61 | 9.5 | 5.1 | 10.3 | 35.1 | 37 | 31 | 30 | 6 | 20 | 40 | 0 | 2 | 6 | 0 | 0 | 3 | 4 | 4.91 |