| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 13 | 13 | 3 | 6 | 4.80 | .331 | 1.45 | 9.3 | 3.8 | 7.0 | 84.1 | 87 | 48 | 45 | 15 | 35 | 65 | 2 | 0 | 0 | 0 | 5 | 3 | 4 | 5.13 |
| SP | Young, C.Young, Chris # >> | 28 | 2007 | R | 82 | 13 | 13 | 5 | 2 | 4.58 | .313 | 1.33 | 8.4 | 3.7 | 8.5 | 76.2 | 71 | 39 | 39 | 16 | 31 | 72 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 5.18 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 13 | 13 | 2 | 4 | 5.04 | .346 | 1.57 | 10.0 | 4.3 | 6.5 | 55.1 | 61 | 33 | 31 | 6 | 26 | 40 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.44 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 12 | 12 | 4 | 5 | 5.40 | .386 | 1.83 | 9.0 | 7.5 | 7.7 | 70.0 | 70 | 42 | 42 | 14 | 58 | 60 | 0 | 0 | 0 | 0 | 5 | 4 | 1 | 6.54 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 54 | 12 | 12 | 5 | 2 | 4.94 | .336 | 1.48 | 9.8 | 3.5 | 8.6 | 71.0 | 77 | 39 | 39 | 9 | 28 | 68 | 0 | 0 | 0 | 0 | 5 | 3 | 4 | 4.04 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 31 | 0 | 4 | 1 | 3.38 | .301 | 1.29 | 8.8 | 2.8 | 10.3 | 48.0 | 47 | 18 | 18 | 5 | 15 | 55 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.00 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 31 | 0 | 0 | 5 | 6.00 | .331 | 1.49 | 9.7 | 3.7 | 8.1 | 39.0 | 42 | 28 | 26 | 10 | 16 | 35 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 5.77 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 28 | 0 | 2 | 2 | 3.98 | .265 | 1.08 | 7.4 | 2.5 | 11.0 | 40.2 | 33 | 18 | 18 | 6 | 11 | 49 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.33 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 39 | 27 | 0 | 1 | 2 | 7.39 | .399 | 1.96 | 12.8 | 5.2 | 8.1 | 31.2 | 44 | 26 | 26 | 5 | 18 | 28 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 5.13 |
| SP | Miller, W.Miller, Wade >> | 25 | 2001 | R | 29 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |