| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 15 | 15 | 2 | 7 | 6.75 | .322 | 1.42 | 9.9 | 2.9 | 7.8 | 77.1 | 85 | 58 | 58 | 20 | 25 | 67 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 5.61 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 15 | 15 | 6 | 2 | 3.54 | .308 | 1.30 | 9.3 | 2.4 | 5.5 | 104.1 | 108 | 42 | 41 | 17 | 28 | 63 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 4.81 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 15 | 15 | 6 | 6 | 3.31 | .265 | 1.04 | 6.8 | 2.6 | 6.1 | 100.2 | 76 | 38 | 37 | 13 | 29 | 68 | 0 | 0 | 0 | 0 | 10 | 4 | 0 | 4.32 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 53 | 14 | 14 | 5 | 7 | 5.29 | .340 | 1.54 | 8.0 | 5.9 | 8.3 | 83.1 | 74 | 49 | 49 | 13 | 54 | 77 | 0 | 0 | 0 | 0 | 8 | 1 | 5 | 5.17 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 37 | 0 | 1 | 4 | 3.60 | .302 | 1.30 | 6.8 | 4.9 | 11.7 | 50.0 | 38 | 20 | 20 | 4 | 27 | 65 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.06 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 53 | 32 | 0 | 2 | 1 | 5.14 | .305 | 1.31 | 8.0 | 3.9 | 9.3 | 35.0 | 31 | 22 | 20 | 5 | 15 | 36 | 0 | 6 | 2 | 0 | 0 | 0 | 3 | 4.09 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 42 | 24 | 0 | 2 | 3 | 4.80 | .291 | 1.23 | 8.4 | 2.7 | 12.9 | 30.0 | 28 | 16 | 16 | 2 | 9 | 43 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 1.90 |
| RP | Shields, S.Shields, Scot >> | 30 | 2005 | R | 30 | 19 | 0 | 2 | 0 | 5.82 | .338 | 1.53 | 8.5 | 5.3 | 7.4 | 17.0 | 16 | 12 | 11 | 4 | 10 | 14 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 6.18 |
| SP | Mulder, M.Mulder, Mark >> | 24 | 2001 | L | 29 | 4 | 0 | 0 | 2 | 6.43 | .417 | 2.00 | 15.4 | 2.6 | 6.4 | 7.0 | 12 | 5 | 5 | 2 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.57 |