| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 31 | 31 | 5 | 13 | 4.94 | .313 | 1.35 | 8.6 | 3.6 | 6.5 | 182.1 | 174 | 110 | 100 | 26 | 72 | 131 | 0 | 0 | 0 | 0 | 14 | 3 | 3 | 4.65 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 30 | 30 | 5 | 16 | 5.77 | .345 | 1.55 | 10.9 | 3.0 | 7.7 | 167.0 | 203 | 127 | 107 | 28 | 56 | 143 | 0 | 0 | 0 | 0 | 13 | 5 | 4 | 4.56 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 29 | 29 | 11 | 10 | 5.28 | .352 | 1.59 | 10.5 | 3.8 | 6.6 | 174.0 | 203 | 121 | 102 | 28 | 73 | 128 | 0 | 0 | 0 | 0 | 10 | 8 | 7 | 5.02 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 29 | 29 | 7 | 13 | 6.82 | .365 | 1.69 | 11.9 | 3.2 | 7.2 | 153.0 | 203 | 137 | 116 | 39 | 55 | 123 | 0 | 0 | 0 | 0 | 5 | 6 | 1 | 5.90 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 28 | 28 | 9 | 15 | 6.81 | .360 | 1.65 | 11.5 | 3.4 | 6.5 | 157.1 | 200 | 134 | 119 | 38 | 59 | 113 | 2 | 0 | 0 | 1 | 10 | 7 | 2 | 5.97 |
| RP | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 98 | 83 | 0 | 8 | 3 | 3.53 | .306 | 1.29 | 7.7 | 4.0 | 10.3 | 109.2 | 93 | 45 | 43 | 10 | 48 | 125 | 0 | 4 | 3 | 0 | 0 | 4 | 4 | 3.33 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 76 | 0 | 2 | 4 | 3.83 | .297 | 1.26 | 8.1 | 3.3 | 8.6 | 96.1 | 86 | 50 | 41 | 16 | 35 | 92 | 0 | 5 | 4 | 0 | 0 | 1 | 0 | 4.38 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 59 | 64 | 0 | 3 | 3 | 3.55 | .296 | 1.25 | 7.3 | 3.9 | 9.4 | 76.0 | 62 | 37 | 30 | 10 | 33 | 79 | 0 | 4 | 3 | 0 | 0 | 1 | 2 | 3.97 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 53 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 1 | 0 | 0 | 0 | 13.50 | .333 | 1.50 | 18.0 | 0.0 | 18.0 | 1.1 | 2 | 2 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12.00 |