| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 13 | 13 | 4 | 5 | 4.07 | .313 | 1.32 | 8.0 | 4.0 | 9.8 | 79.2 | 70 | 36 | 36 | 11 | 35 | 86 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 4.11 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 13 | 13 | 8 | 3 | 4.96 | .315 | 1.37 | 10.4 | 2.0 | 6.9 | 90.2 | 104 | 50 | 50 | 15 | 20 | 69 | 3 | 0 | 0 | 0 | 7 | 1 | 0 | 4.33 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 78 | 13 | 13 | 5 | 5 | 3.62 | .295 | 1.24 | 9.0 | 2.3 | 6.5 | 79.2 | 79 | 36 | 32 | 11 | 20 | 57 | 1 | 0 | 0 | 0 | 9 | 1 | 1 | 4.16 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 12 | 12 | 4 | 7 | 4.34 | .307 | 1.29 | 8.9 | 2.8 | 7.8 | 74.2 | 73 | 39 | 36 | 12 | 23 | 64 | 2 | 0 | 0 | 1 | 4 | 3 | 2 | 4.43 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 12 | 12 | 6 | 3 | 4.39 | .310 | 1.35 | 8.9 | 3.4 | 6.9 | 69.2 | 68 | 40 | 34 | 12 | 26 | 53 | 0 | 0 | 0 | 0 | 7 | 0 | 2 | 4.86 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 30 | 0 | 3 | 0 | 4.46 | .299 | 1.25 | 8.5 | 2.8 | 4.5 | 38.1 | 36 | 22 | 19 | 7 | 12 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.42 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 33 | 0 | 1 | 0 | 3.77 | .345 | 1.58 | 9.9 | 4.4 | 11.0 | 31.0 | 34 | 16 | 13 | 4 | 15 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.68 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 16 | 0 | 0 | 1 | 2.78 | .320 | 1.41 | 7.4 | 5.7 | 3.3 | 22.2 | 18 | 9 | 7 | 1 | 14 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.77 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 56 | 21 | 0 | 1 | 0 | 1.80 | .279 | 1.12 | 7.9 | 2.2 | 9.7 | 25.0 | 22 | 6 | 5 | 3 | 6 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.24 |