| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 14 | 14 | 7 | 5 | 4.03 | .301 | 1.27 | 9.3 | 2.2 | 11.9 | 96.0 | 99 | 45 | 43 | 14 | 23 | 127 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 3.03 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 86 | 15 | 14 | 5 | 3 | 4.18 | .312 | 1.30 | 9.5 | 2.3 | 7.9 | 94.2 | 99 | 48 | 44 | 13 | 24 | 82 | 1 | 0 | 0 | 0 | 8 | 6 | 0 | 4.01 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 15 | 15 | 4 | 5 | 4.70 | .332 | 1.45 | 9.3 | 3.8 | 6.1 | 88.0 | 91 | 48 | 46 | 13 | 37 | 60 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 4.92 |
| SP | Williams, W.Williams, Woody # >> | 36 | 2002 | R | 78 | 14 | 14 | 5 | 4 | 4.98 | .317 | 1.37 | 9.2 | 3.2 | 5.2 | 90.1 | 92 | 52 | 50 | 16 | 32 | 52 | 1 | 0 | 0 | 1 | 6 | 2 | 0 | 5.29 |
| SP | Haren, D.Haren, Dan # $ >> | 29 | 2009 | R | 85 | 14 | 13 | 4 | 6 | 5.36 | .336 | 1.49 | 11.4 | 2.1 | 8.1 | 82.1 | 104 | 53 | 49 | 14 | 19 | 74 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.18 |
| CL | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 26 | 0 | 3 | 0 | 0.70 | .260 | 1.05 | 5.8 | 4.0 | 12.2 | 25.2 | 16 | 2 | 2 | 1 | 11 | 34 | 0 | 12 | 1 | 0 | 0 | 0 | 2 | 2.12 |
| SU | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 17 | 0 | 2 | 0 | 3.20 | .192 | 0.71 | 5.2 | 1.4 | 10.9 | 19.2 | 11 | 7 | 7 | 3 | 3 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.11 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 28 | 0 | 2 | 0 | 4.45 | .325 | 1.41 | 9.0 | 3.9 | 10.6 | 28.1 | 28 | 19 | 14 | 0 | 12 | 33 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 2.04 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 17 | 0 | 0 | 1 | 4.50 | .333 | 1.44 | 7.9 | 5.1 | 6.2 | 16.0 | 14 | 9 | 8 | 2 | 9 | 11 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 5.13 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 20 | 0 | 1 | 1 | 5.32 | .340 | 1.45 | 7.8 | 5.3 | 8.2 | 22.0 | 19 | 14 | 13 | 4 | 13 | 20 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.59 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 58 | 9 | 3 | 1 | 3 | 6.27 | .309 | 1.29 | 9.0 | 2.7 | 5.1 | 37.1 | 37 | 26 | 26 | 8 | 11 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.73 |