| SP | Haren, D.Haren, Dan † # >> | 29 | 2009 | R | 85 | 29 | 29 | 13 | 7 | 3.86 | .290 | 1.18 | 8.6 | 2.1 | 7.4 | 200.2 | 190 | 97 | 86 | 35 | 47 | 165 | 3 | 0 | 0 | 0 | 19 | 9 | 5 | 4.47 |
| SP | Schmidt, J.Schmidt, Jason † # >> | 30 | 2003 | R | 99 | 30 | 30 | 15 | 10 | 4.25 | .313 | 1.32 | 8.4 | 3.6 | 8.4 | 197.0 | 183 | 97 | 93 | 17 | 78 | 183 | 3 | 0 | 0 | 3 | 16 | 8 | 5 | 3.57 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 58 | 30 | 30 | 9 | 12 | 4.53 | .310 | 1.31 | 8.7 | 3.2 | 7.2 | 188.2 | 181 | 100 | 95 | 28 | 66 | 151 | 1 | 0 | 0 | 1 | 16 | 7 | 3 | 4.49 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 79 | 28 | 28 | 11 | 9 | 4.58 | .321 | 1.39 | 9.2 | 3.3 | 5.6 | 173.0 | 177 | 93 | 88 | 21 | 63 | 107 | 3 | 0 | 0 | 1 | 14 | 5 | 4 | 4.52 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 28 | 19 | 6 | 12 | 4.81 | .322 | 1.39 | 9.4 | 3.1 | 9.1 | 162.2 | 170 | 94 | 87 | 28 | 56 | 164 | 1 | 0 | 0 | 1 | 11 | 6 | 5 | 4.37 |
| CL | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 58 | 0 | 4 | 1 | 2.66 | .291 | 1.21 | 6.3 | 4.6 | 11.1 | 61.0 | 43 | 20 | 18 | 6 | 31 | 75 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.39 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 39 | 0 | 2 | 1 | 3.10 | .303 | 1.28 | 9.9 | 1.8 | 8.6 | 40.2 | 44 | 14 | 14 | 6 | 8 | 38 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.73 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 85 | 46 | 0 | 3 | 3 | 3.12 | .310 | 1.33 | 6.8 | 5.1 | 9.7 | 49.0 | 37 | 19 | 17 | 5 | 28 | 53 | 0 | 10 | 2 | 0 | 0 | 1 | 1 | 3.94 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 43 | 0 | 4 | 3 | 3.38 | .230 | 0.88 | 4.5 | 3.4 | 7.9 | 48.0 | 24 | 18 | 18 | 5 | 18 | 42 | 0 | 10 | 5 | 0 | 0 | 1 | 0 | 3.79 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 51 | 0 | 3 | 0 | 3.76 | .304 | 1.27 | 8.1 | 3.5 | 11.6 | 52.2 | 47 | 25 | 22 | 9 | 20 | 67 | 0 | 5 | 1 | 0 | 0 | 2 | 1 | 3.94 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 34 | 0 | 3 | 6 | 4.54 | .308 | 1.34 | 10.9 | 1.4 | 11.5 | 33.2 | 40 | 17 | 17 | 5 | 5 | 42 | 0 | 4 | 2 | 0 | 0 | 0 | 3 | 2.88 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 100 | 28 | 0 | 1 | 3 | 4.55 | .284 | 1.12 | 6.7 | 3.7 | 10.0 | 27.2 | 20 | 14 | 14 | 6 | 11 | 30 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.11 |
| SP | Maine, J.Maine, John # >> | 25 | 2006 | R | 69 | 23 | 11 | 3 | 3 | 6.35 | .341 | 1.53 | 9.5 | 4.4 | 5.9 | 90.2 | 95 | 68 | 64 | 22 | 44 | 59 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 6.40 |