| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 20 | 20 | 4 | 10 | 4.76 | .286 | 1.17 | 8.4 | 2.2 | 9.8 | 147.1 | 137 | 80 | 78 | 26 | 36 | 160 | 4 | 0 | 0 | 0 | 7 | 4 | 4 | 3.94 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 19 | 19 | 6 | 7 | 3.78 | .298 | 1.21 | 7.9 | 3.0 | 8.3 | 126.1 | 111 | 57 | 53 | 17 | 42 | 116 | 0 | 0 | 0 | 0 | 11 | 8 | 0 | 4.10 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 19 | 19 | 5 | 4 | 4.53 | .295 | 1.20 | 8.9 | 1.9 | 6.5 | 89.1 | 88 | 48 | 45 | 17 | 19 | 64 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 4.85 |
| CL | Rivera, M.Rivera, Mariano $$ >> | 39 | 2008 | R | 96 | 43 | 0 | 0 | 5 | 3.42 | .268 | 1.08 | 7.2 | 2.5 | 9.5 | 50.0 | 40 | 20 | 19 | 3 | 14 | 53 | 0 | 24 | 2 | 0 | 0 | 1 | 0 | 2.56 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 26 | 0 | 3 | 1 | 4.97 | .336 | 1.41 | 9.9 | 2.8 | 9.9 | 29.0 | 32 | 16 | 16 | 4 | 9 | 32 | 0 | 2 | 6 | 0 | 0 | 3 | 1 | 3.83 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 50 | 0 | 6 | 3 | 4.04 | .277 | 1.11 | 7.9 | 2.3 | 10.1 | 55.2 | 48 | 25 | 25 | 4 | 14 | 62 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 2.56 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 33 | 0 | 7 | 0 | 2.21 | .231 | 0.87 | 3.8 | 4.3 | 10.0 | 36.2 | 15 | 9 | 9 | 3 | 17 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.36 |
| RP | Springer, R.Springer, Russ >> | 39 | 2007 | R | 79 | 30 | 0 | 5 | 3 | 2.88 | .304 | 1.28 | 7.9 | 3.7 | 9.5 | 34.1 | 30 | 11 | 11 | 3 | 14 | 36 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.35 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 15 | 0 | 1 | 1 | 8.56 | .397 | 1.90 | 13.8 | 4.2 | 9.7 | 13.2 | 20 | 13 | 13 | 4 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 6.46 |