| SP | Liriano, F.Liriano, Francisco # $ >> | 23 | 2006 | L | 98 | 18 | 18 | 4 | 3 | 5.77 | .332 | 1.46 | 10.3 | 3.0 | 8.8 | 82.2 | 94 | 53 | 53 | 10 | 27 | 80 | 0 | 0 | 0 | 0 | 2 | 2 | 5 | 3.70 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 18 | 18 | 8 | 6 | 5.53 | .320 | 1.38 | 8.8 | 3.7 | 8.3 | 110.2 | 108 | 71 | 68 | 21 | 45 | 101 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 4.95 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 79 | 17 | 17 | 5 | 8 | 6.51 | .337 | 1.48 | 10.5 | 2.7 | 5.7 | 105.0 | 123 | 83 | 76 | 17 | 32 | 67 | 1 | 0 | 0 | 0 | 7 | 5 | 2 | 4.89 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 17 | 17 | 7 | 5 | 6.62 | .360 | 1.63 | 11.7 | 3.1 | 6.8 | 100.2 | 130 | 77 | 74 | 21 | 34 | 75 | 0 | 0 | 0 | 0 | 7 | 6 | 1 | 5.43 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 17 | 17 | 6 | 8 | 7.05 | .371 | 1.74 | 12.2 | 3.5 | 7.3 | 103.1 | 140 | 85 | 81 | 22 | 40 | 83 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 5.42 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 32 | 0 | 5 | 2 | 2.18 | .283 | 1.15 | 8.2 | 2.2 | 7.4 | 33.0 | 30 | 14 | 8 | 3 | 8 | 27 | 0 | 16 | 1 | 0 | 0 | 1 | 1 | 3.36 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 29 | 0 | 1 | 2 | 6.00 | .365 | 1.67 | 10.9 | 4.1 | 8.2 | 33.0 | 40 | 23 | 22 | 3 | 15 | 30 | 0 | 3 | 5 | 0 | 0 | 2 | 1 | 3.91 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 42 | 0 | 4 | 2 | 4.31 | .332 | 1.40 | 9.0 | 3.7 | 6.9 | 56.1 | 56 | 28 | 27 | 10 | 23 | 43 | 0 | 1 | 2 | 0 | 0 | 5 | 1 | 5.29 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 34 | 0 | 2 | 0 | 3.43 | .293 | 1.25 | 7.4 | 3.9 | 7.6 | 39.1 | 32 | 16 | 15 | 6 | 17 | 33 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.62 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 24 | 0 | 0 | 0 | 2.86 | .292 | 1.20 | 7.1 | 3.9 | 7.7 | 28.1 | 22 | 9 | 9 | 3 | 12 | 24 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.07 |