| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 20 | 20 | 6 | 8 | 4.18 | .298 | 1.23 | 8.0 | 3.1 | 8.1 | 137.2 | 122 | 66 | 64 | 21 | 47 | 123 | 2 | 0 | 0 | 0 | 10 | 6 | 4 | 4.36 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 86 | 20 | 20 | 3 | 12 | 6.19 | .335 | 1.48 | 10.3 | 3.1 | 9.2 | 120.2 | 137 | 85 | 83 | 23 | 41 | 123 | 3 | 0 | 0 | 0 | 5 | 4 | 5 | 4.57 |
| SP | Greinke, Z.Greinke, Zack >> | 26 | 2009 | R | 77 | 19 | 19 | 8 | 6 | 3.55 | .288 | 1.21 | 8.2 | 2.7 | 9.9 | 124.1 | 113 | 55 | 49 | 20 | 37 | 136 | 0 | 0 | 0 | 0 | 13 | 1 | 3 | 3.82 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 19 | 19 | 7 | 7 | 5.16 | .316 | 1.37 | 9.8 | 2.5 | 5.7 | 113.1 | 123 | 69 | 65 | 17 | 32 | 72 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 4.58 |
| RP | Soria, J.Soria, Joakim † >> | 24 | 2008 | R | 88 | 55 | 0 | 5 | 0 | 2.68 | .262 | 1.04 | 7.3 | 2.1 | 6.8 | 74.0 | 60 | 23 | 22 | 6 | 17 | 56 | 0 | 6 | 0 | 0 | 0 | 2 | 3 | 3.31 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 42 | 0 | 3 | 5 | 5.65 | .308 | 1.27 | 8.5 | 3.0 | 8.8 | 51.0 | 48 | 32 | 32 | 12 | 17 | 50 | 0 | 2 | 1 | 0 | 0 | 3 | 2 | 5.27 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 64 | 32 | 0 | 2 | 1 | 2.29 | .239 | 0.94 | 6.0 | 2.5 | 8.8 | 39.1 | 26 | 11 | 10 | 5 | 11 | 38 | 0 | 0 | 3 | 0 | 0 | 0 | 4 | 3.56 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 59 | 25 | 0 | 1 | 3 | 4.91 | .336 | 1.52 | 10.8 | 3.2 | 8.6 | 25.2 | 30 | 16 | 14 | 3 | 9 | 24 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 3.72 |