| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 93 | 15 | 15 | 5 | 4 | 4.14 | .259 | 1.03 | 7.7 | 1.6 | 10.9 | 115.1 | 99 | 54 | 53 | 20 | 20 | 139 | 3 | 0 | 0 | 1 | 8 | 2 | 2 | 3.42 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 15 | 15 | 1 | 4 | 3.97 | .319 | 1.37 | 8.4 | 4.0 | 7.2 | 59.0 | 55 | 26 | 26 | 6 | 26 | 47 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 4.15 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 15 | 15 | 3 | 8 | 6.44 | .386 | 1.82 | 10.9 | 5.6 | 6.4 | 79.2 | 96 | 60 | 57 | 10 | 49 | 56 | 0 | 0 | 0 | 0 | 6 | 5 | 2 | 5.28 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 14 | 14 | 4 | 5 | 4.88 | .352 | 1.59 | 11.1 | 3.3 | 5.8 | 86.2 | 106 | 48 | 47 | 13 | 32 | 55 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 4.91 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 14 | 14 | 5 | 5 | 4.01 | .333 | 1.47 | 8.1 | 5.1 | 6.8 | 92.0 | 83 | 45 | 41 | 8 | 52 | 69 | 1 | 0 | 0 | 1 | 6 | 3 | 2 | 4.42 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 37 | 0 | 5 | 3 | 2.95 | .267 | 1.05 | 6.9 | 2.6 | 7.9 | 55.0 | 42 | 18 | 18 | 4 | 16 | 48 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.18 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 28 | 0 | 2 | 3 | 3.86 | .304 | 1.29 | 6.3 | 5.4 | 5.1 | 37.1 | 26 | 16 | 16 | 1 | 22 | 21 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 4.08 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 28 | 0 | 2 | 1 | 4.99 | .338 | 1.50 | 9.0 | 4.8 | 8.1 | 30.2 | 30 | 17 | 17 | 6 | 16 | 27 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 5.50 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 23 | 23 | 0 | 1 | 0 | 4.74 | .368 | 1.66 | 10.1 | 5.3 | 11.3 | 24.2 | 27 | 15 | 13 | 5 | 14 | 30 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 5.21 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 1 | 0 | 0 | 0 | 0.00 | .500 | 3.00 | - | - | - | 0.1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Person, R.Person, Robert >> | 32 | 2001 | R | 24 | 15 | 0 | 2 | 2 | 3.33 | .336 | 1.44 | 9.0 | 4.1 | 4.5 | 24.1 | 24 | 9 | 9 | 3 | 11 | 12 | 0 | 2 | 1 | 0 | 0 | 2 | 2 | 5.25 |