| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 95 | 20 | 20 | 6 | 4 | 3.45 | .294 | 1.23 | 7.7 | 3.4 | 9.6 | 122.2 | 105 | 51 | 47 | 9 | 46 | 130 | 0 | 0 | 0 | 0 | 13 | 2 | 2 | 3.01 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 19 | 19 | 2 | 11 | 6.62 | .358 | 1.65 | 11.7 | 3.2 | 7.6 | 103.1 | 134 | 76 | 76 | 22 | 37 | 87 | 0 | 0 | 0 | 0 | 5 | 2 | 3 | 5.22 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 75 | 19 | 19 | 9 | 4 | 3.68 | .313 | 1.33 | 7.8 | 4.2 | 9.1 | 127.1 | 110 | 56 | 52 | 16 | 59 | 128 | 1 | 0 | 0 | 0 | 13 | 5 | 1 | 4.13 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 54 | 19 | 19 | 4 | 9 | 6.46 | .356 | 1.63 | 11.0 | 3.8 | 6.4 | 108.2 | 132 | 79 | 78 | 22 | 45 | 77 | 0 | 0 | 0 | 0 | 7 | 3 | 4 | 5.56 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 50 | 0 | 3 | 5 | 4.39 | .312 | 1.36 | 7.0 | 5.4 | 9.0 | 67.2 | 52 | 33 | 33 | 5 | 40 | 67 | 0 | 3 | 4 | 0 | 0 | 0 | 7 | 3.76 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 36 | 0 | 3 | 4 | 6.19 | .339 | 1.51 | 10.0 | 3.8 | 10.5 | 36.1 | 40 | 25 | 25 | 4 | 15 | 42 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.44 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 43 | 30 | 0 | 3 | 2 | 5.64 | .345 | 1.52 | 9.3 | 4.5 | 8.7 | 30.1 | 31 | 19 | 19 | 3 | 15 | 29 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 4.07 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 31 | 28 | 0 | 2 | 1 | 5.91 | .338 | 1.50 | 9.6 | 3.9 | 10.1 | 32.0 | 34 | 21 | 21 | 8 | 14 | 36 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 5.41 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 1 | 0 | 0 | 0 | 6.00 | .400 | 2.00 | 15.0 | 3.0 | 6.0 | 3.0 | 5 | 2 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.00 |
| SP | Washburn, J.Washburn, Jarrod >> | 28 | 2002 | L | 31 | 14 | 0 | 0 | 2 | 4.37 | .327 | 1.37 | 9.0 | 3.7 | 4.1 | 22.2 | 22 | 11 | 11 | 5 | 9 | 10 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 6.55 |