| SP | Hernandez, F.Hernandez, Felix † $$ >> | 19 | 2005 | R | 96 | 20 | 20 | 12 | 5 | 2.76 | .276 | 1.10 | 7.3 | 2.6 | 7.2 | 143.1 | 116 | 45 | 44 | 7 | 42 | 114 | 4 | 0 | 0 | 1 | 15 | 6 | 2 | 3.05 |
| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 77 | 19 | 19 | 2 | 4 | 5.33 | .312 | 1.34 | 9.4 | 2.6 | 6.3 | 103.0 | 108 | 61 | 61 | 16 | 30 | 72 | 1 | 0 | 0 | 1 | 8 | 2 | 4 | 4.55 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 19 | 19 | 8 | 5 | 5.57 | .342 | 1.50 | 10.2 | 3.3 | 5.9 | 105.0 | 119 | 65 | 65 | 12 | 39 | 69 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 4.46 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 57 | 18 | 18 | 6 | 5 | 5.32 | .315 | 1.37 | 10.0 | 2.4 | 6.5 | 106.2 | 118 | 68 | 63 | 15 | 28 | 76 | 3 | 0 | 0 | 1 | 8 | 1 | 3 | 4.23 |
| RP | Soriano, R.Soriano, Rafael $ >> | 24 | 2003 | R | 97 | 59 | 0 | 3 | 1 | 3.57 | .276 | 1.14 | 7.1 | 3.1 | 8.3 | 63.0 | 50 | 26 | 25 | 7 | 22 | 58 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 3.65 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 46 | 0 | 4 | 5 | 4.11 | .332 | 1.49 | 10.1 | 3.4 | 7.0 | 50.1 | 56 | 24 | 23 | 6 | 19 | 39 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 4.14 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 86 | 38 | 0 | 2 | 3 | 3.72 | .323 | 1.43 | 7.8 | 5.3 | 10.5 | 36.1 | 31 | 15 | 15 | 3 | 21 | 42 | 0 | 6 | 3 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 80 | 19 | 0 | 0 | 1 | 2.53 | .347 | 1.59 | 9.9 | 4.7 | 9.0 | 21.1 | 23 | 6 | 6 | 0 | 11 | 21 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.57 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 18 | 0 | 2 | 1 | 1.31 | .184 | 0.68 | 5.4 | 0.9 | 12.2 | 20.2 | 12 | 3 | 3 | 1 | 2 | 27 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.25 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 58 | 0 | 4 | 5 | 3.95 | .297 | 1.25 | 8.2 | 3.1 | 10.5 | 43.1 | 39 | 19 | 19 | 5 | 15 | 50 | 0 | 2 | 3 | 0 | 0 | 1 | 6 | 3.30 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 23 | 0 | 6 | 4 | 4.82 | .288 | 1.21 | 8.2 | 2.7 | 5.3 | 71.0 | 65 | 39 | 38 | 8 | 21 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.17 |