| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 34 | 34 | 2 | 14 | 4.52 | .341 | 1.51 | 10.2 | 3.5 | 9.2 | 147.1 | 166 | 77 | 74 | 24 | 57 | 151 | 0 | 0 | 0 | 0 | 2 | 6 | 5 | 4.35 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 33 | 33 | 5 | 22 | 6.22 | .356 | 1.60 | 10.4 | 4.0 | 7.7 | 205.1 | 238 | 150 | 142 | 41 | 91 | 176 | 1 | 0 | 0 | 0 | 12 | 11 | 5 | 5.38 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 32 | 32 | 6 | 10 | 5.50 | .348 | 1.56 | 9.5 | 4.6 | 7.9 | 188.1 | 198 | 122 | 115 | 32 | 96 | 166 | 0 | 0 | 0 | 0 | 10 | 8 | 2 | 5.11 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 32 | 31 | 9 | 16 | 5.65 | .329 | 1.43 | 9.8 | 3.1 | 6.5 | 188.0 | 204 | 124 | 118 | 40 | 65 | 135 | 1 | 0 | 1 | 0 | 11 | 8 | 1 | 5.49 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 102 | 0 | 11 | 6 | 4.51 | .305 | 1.29 | 8.6 | 3.0 | 9.5 | 145.2 | 139 | 75 | 73 | 26 | 49 | 153 | 0 | 3 | 7 | 0 | 0 | 4 | 2 | 4.32 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 92 | 0 | 5 | 10 | 4.48 | .323 | 1.38 | 8.0 | 4.4 | 7.9 | 120.2 | 107 | 60 | 60 | 18 | 59 | 105 | 0 | 2 | 3 | 0 | 0 | 7 | 3 | 4.85 |
| RP | Springer, R.Springer, Russ † >> | 39 | 2007 | R | 78 | 86 | 0 | 7 | 3 | 2.20 | .276 | 1.11 | 6.2 | 3.8 | 9.6 | 114.2 | 79 | 30 | 28 | 9 | 48 | 121 | 0 | 12 | 4 | 0 | 0 | 4 | 2 | 3.27 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 66 | 0 | 3 | 5 | 3.69 | .304 | 1.27 | 7.5 | 3.9 | 9.0 | 83.0 | 69 | 35 | 34 | 12 | 36 | 83 | 0 | 8 | 3 | 0 | 0 | 4 | 3 | 4.33 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 51 | 58 | 0 | 4 | 3 | 5.90 | .333 | 1.46 | 8.6 | 4.6 | 8.6 | 68.2 | 65 | 46 | 45 | 11 | 35 | 65 | 0 | 4 | 2 | 0 | 0 | 3 | 5 | 4.87 |