| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 38 | 38 | 20 | 11 | 3.60 | .293 | 1.21 | 8.3 | 2.7 | 10.2 | 262.2 | 241 | 117 | 105 | 38 | 78 | 297 | 5 | 0 | 0 | 2 | 22 | 8 | 4 | 3.60 |
| SP | Peavy, J.Peavy, Jake † # >> | 26 | 2007 | R | 88 | 35 | 35 | 20 | 8 | 4.46 | .307 | 1.33 | 8.8 | 3.2 | 9.2 | 220.0 | 216 | 111 | 109 | 26 | 77 | 224 | 1 | 0 | 0 | 1 | 20 | 0 | 5 | 3.55 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 34 | 34 | 16 | 7 | 5.48 | .332 | 1.47 | 10.5 | 2.8 | 6.4 | 198.2 | 231 | 125 | 121 | 34 | 62 | 140 | 1 | 0 | 0 | 0 | 15 | 3 | 7 | 4.80 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 34 | 34 | 12 | 10 | 5.94 | .342 | 1.54 | 11.3 | 2.5 | 7.3 | 195.1 | 245 | 135 | 129 | 26 | 55 | 158 | 0 | 0 | 0 | 0 | 12 | 5 | 11 | 4.04 |
| SP | Loaiza, E.Loaiza, Esteban † >> | 32 | 2003 | R | 58 | 33 | 31 | 17 | 6 | 3.88 | .310 | 1.33 | 9.5 | 2.6 | 7.2 | 199.2 | 209 | 89 | 86 | 20 | 57 | 160 | 2 | 1 | 0 | 1 | 19 | 3 | 3 | 3.60 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 98 | 0 | 9 | 4 | 4.26 | .298 | 1.25 | 8.7 | 2.6 | 9.4 | 118.1 | 114 | 57 | 56 | 19 | 34 | 123 | 0 | 3 | 3 | 0 | 0 | 3 | 1 | 3.95 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 83 | 0 | 6 | 5 | 4.15 | .300 | 1.28 | 8.8 | 2.7 | 10.8 | 93.1 | 91 | 43 | 43 | 13 | 28 | 112 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 3.34 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 53 | 69 | 0 | 2 | 3 | 6.01 | .316 | 1.38 | 9.4 | 3.1 | 9.1 | 76.1 | 79 | 52 | 51 | 15 | 26 | 77 | 0 | 0 | 3 | 0 | 0 | 1 | 4 | 4.61 |
| SU | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 76 | 0 | 1 | 5 | 4.30 | .328 | 1.46 | 7.3 | 5.8 | 10.8 | 90.0 | 73 | 49 | 43 | 13 | 58 | 108 | 0 | 6 | 8 | 0 | 0 | 1 | 2 | 4.44 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 87 | 0 | 7 | 3 | 2.82 | .282 | 1.15 | 6.8 | 3.7 | 10.8 | 92.2 | 69 | 30 | 29 | 11 | 38 | 110 | 0 | 44 | 1 | 0 | 0 | 2 | 2 | 3.47 |