| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 89 | 29 | 29 | 19 | 0 | 2.56 | .268 | 1.07 | 6.9 | 2.7 | 9.0 | 207.1 | 159 | 61 | 59 | 23 | 62 | 207 | 4 | 0 | 0 | 2 | 24 | 7 | 4 | 3.44 |
| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 31 | 31 | 13 | 11 | 3.13 | .261 | 1.02 | 7.1 | 2.1 | 9.4 | 207.0 | 163 | 73 | 72 | 20 | 49 | 216 | 1 | 0 | 0 | 0 | 23 | 7 | 0 | 2.98 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 64 | 0 | 3 | 3 | 1.76 | .251 | 0.96 | 5.9 | 2.9 | 9.4 | 66.2 | 43 | 14 | 13 | 5 | 21 | 69 | 0 | 42 | 4 | 0 | 0 | 3 | 0 | 2.98 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 92 | 59 | 0 | 2 | 2 | 2.20 | .274 | 1.13 | 5.8 | 4.4 | 10.6 | 57.1 | 37 | 19 | 14 | 3 | 28 | 67 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 2.81 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 72 | 74 | 0 | 0 | 0 | 2.87 | .285 | 1.18 | 6.7 | 4.1 | 7.7 | 62.2 | 46 | 20 | 20 | 7 | 28 | 53 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 4.16 |
| RP | Davis, W.Davis, Wade # >> | 29 | 2015 | R | 87 | 67 | 0 | 6 | 4 | 4.14 | .287 | 1.19 | 7.4 | 3.4 | 9.0 | 58.2 | 48 | 28 | 27 | 8 | 22 | 58 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.98 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 54 | 30 | 0 | 3 | 0 | 2.28 | .343 | 1.52 | 7.8 | 6.3 | 2.7 | 23.2 | 20 | 6 | 6 | 0 | 16 | 7 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.61 |