| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 32 | 32 | 13 | 14 | 3.86 | .271 | 1.10 | 7.9 | 1.9 | 9.2 | 231.0 | 204 | 101 | 99 | 34 | 50 | 235 | 10 | 0 | 0 | 2 | 19 | 3 | 2 | 3.57 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 32 | 32 | 12 | 8 | 4.91 | .320 | 1.40 | 9.5 | 3.1 | 9.0 | 198.0 | 208 | 111 | 108 | 26 | 69 | 197 | 1 | 0 | 0 | 1 | 16 | 2 | 4 | 3.79 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 81 | 31 | 31 | 12 | 15 | 5.04 | .323 | 1.42 | 9.5 | 3.3 | 8.1 | 205.1 | 216 | 116 | 115 | 31 | 75 | 185 | 4 | 0 | 0 | 1 | 12 | 3 | 2 | 4.30 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 69 | 31 | 31 | 15 | 11 | 4.47 | .316 | 1.34 | 9.2 | 2.9 | 6.6 | 217.2 | 223 | 110 | 108 | 36 | 69 | 160 | 5 | 0 | 0 | 0 | 16 | 9 | 2 | 4.76 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 30 | 30 | 19 | 8 | 4.07 | .300 | 1.27 | 8.2 | 3.2 | 4.9 | 221.1 | 202 | 104 | 100 | 27 | 79 | 120 | 6 | 0 | 0 | 1 | 15 | 3 | 10 | 4.62 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 56 | 0 | 2 | 5 | 3.54 | .320 | 1.39 | 8.6 | 4.0 | 11.1 | 61.0 | 58 | 25 | 24 | 2 | 27 | 75 | 0 | 35 | 6 | 0 | 0 | 1 | 4 | 2.34 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 47 | 0 | 1 | 1 | 4.24 | .275 | 1.11 | 6.7 | 3.5 | 10.4 | 46.2 | 34 | 22 | 22 | 7 | 18 | 53 | 0 | 6 | 4 | 0 | 0 | 1 | 0 | 3.91 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 43 | 0 | 4 | 2 | 1.54 | .255 | 0.99 | 6.5 | 2.5 | 9.2 | 46.2 | 33 | 8 | 8 | 3 | 13 | 47 | 0 | 0 | 1 | 0 | 0 | 2 | 7 | 2.78 |