| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 27 | 27 | 12 | 10 | 3.22 | .290 | 1.21 | 8.2 | 2.7 | 8.8 | 207.0 | 188 | 81 | 74 | 18 | 63 | 202 | 8 | 0 | 0 | 2 | 16 | 3 | 3 | 3.14 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 70 | 26 | 26 | 8 | 12 | 5.05 | .316 | 1.37 | 8.8 | 3.6 | 7.0 | 160.1 | 156 | 94 | 90 | 25 | 64 | 125 | 0 | 0 | 0 | 0 | 15 | 2 | 3 | 4.71 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 25 | 25 | 9 | 11 | 4.70 | .319 | 1.39 | 10.0 | 2.5 | 6.1 | 149.1 | 166 | 81 | 78 | 28 | 42 | 101 | 0 | 0 | 0 | 0 | 12 | 2 | 2 | 4.97 |
| SP | Beckett, J.Beckett, Josh # >> | 31 | 2011 | R | 56 | 25 | 25 | 6 | 11 | 5.90 | .357 | 1.66 | 10.6 | 4.3 | 7.2 | 143.1 | 169 | 103 | 94 | 30 | 69 | 115 | 2 | 0 | 0 | 0 | 11 | 1 | 3 | 5.59 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 52 | 24 | 23 | 6 | 13 | 6.89 | .363 | 1.69 | 12.2 | 3.1 | 6.5 | 126.2 | 171 | 98 | 97 | 30 | 43 | 91 | 1 | 0 | 0 | 0 | 6 | 3 | 6 | 5.75 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 94 | 64 | 0 | 1 | 3 | 3.21 | .311 | 1.31 | 5.0 | 6.8 | 10.3 | 84.0 | 47 | 32 | 30 | 5 | 63 | 96 | 0 | 9 | 2 | 0 | 0 | 4 | 10 | 3.88 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 64 | 0 | 2 | 5 | 4.40 | .289 | 1.17 | 7.3 | 3.2 | 9.8 | 86.0 | 70 | 43 | 42 | 14 | 31 | 94 | 0 | 4 | 6 | 0 | 0 | 4 | 5 | 4.15 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 48 | 42 | 0 | 1 | 4 | 10.94 | .417 | 2.12 | 12.3 | 7.1 | 9.5 | 38.2 | 52 | 47 | 47 | 10 | 30 | 40 | 0 | 6 | 2 | 0 | 0 | 1 | 2 | 6.76 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 40 | 41 | 0 | 1 | 2 | 3.20 | .318 | 1.36 | 6.4 | 5.8 | 8.6 | 45.0 | 32 | 17 | 16 | 7 | 29 | 43 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 5.18 |