| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 85 | 24 | 24 | 2 | 6 | 3.84 | .284 | 1.18 | 7.9 | 2.7 | 6.5 | 96.0 | 84 | 42 | 41 | 14 | 29 | 69 | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 4.40 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 25 | 25 | 9 | 10 | 3.86 | .297 | 1.23 | 8.8 | 2.3 | 7.8 | 167.2 | 164 | 75 | 72 | 19 | 42 | 144 | 2 | 0 | 0 | 1 | 12 | 7 | 7 | 3.63 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 24 | 24 | 6 | 7 | 5.67 | .366 | 1.71 | 9.6 | 5.8 | 6.3 | 108.0 | 115 | 73 | 68 | 13 | 70 | 75 | 0 | 0 | 0 | 0 | 3 | 2 | 5 | 5.18 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 67 | 0 | 10 | 6 | 3.58 | .308 | 1.33 | 9.1 | 2.9 | 9.8 | 93.0 | 94 | 38 | 37 | 7 | 30 | 101 | 0 | 5 | 3 | 0 | 0 | 0 | 2 | 2.77 |
| RP | Soria, J.Soria, Joakim † >> | 24 | 2008 | R | 88 | 64 | 0 | 10 | 4 | 3.07 | .290 | 1.12 | 6.5 | 3.6 | 6.8 | 85.0 | 61 | 29 | 29 | 8 | 34 | 64 | 0 | 5 | 4 | 0 | 0 | 9 | 1 | 4.24 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 53 | 0 | 4 | 4 | 4.26 | .310 | 1.30 | 9.0 | 2.8 | 6.6 | 67.2 | 67 | 34 | 32 | 7 | 21 | 49 | 0 | 3 | 3 | 0 | 0 | 3 | 0 | 3.97 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 55 | 0 | 1 | 3 | 3.20 | .284 | 1.19 | 6.2 | 4.6 | 10.7 | 64.2 | 44 | 24 | 23 | 2 | 33 | 76 | 0 | 8 | 0 | 0 | 0 | 0 | 3 | 2.58 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 51 | 40 | 0 | 4 | 3 | 3.58 | .291 | 1.23 | 8.6 | 2.5 | 5.0 | 50.1 | 48 | 20 | 20 | 6 | 14 | 28 | 0 | 3 | 5 | 0 | 0 | 0 | 1 | 4.28 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 32 | 0 | 3 | 1 | 2.95 | .261 | 1.06 | 7.4 | 2.3 | 7.4 | 39.2 | 32 | 13 | 13 | 4 | 10 | 32 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.46 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 84 | 13 | 2 | 0 | 3 | 2.32 | .285 | 1.13 | 7.3 | 2.9 | 5.2 | 31.0 | 25 | 9 | 8 | 2 | 10 | 18 | 0 | 4 | 0 | 0 | 2 | 2 | 1 | 3.84 |