| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 26 | 26 | 10 | 10 | 5.20 | .328 | 1.44 | 8.7 | 4.3 | 6.8 | 174.2 | 168 | 107 | 101 | 13 | 83 | 131 | 4 | 0 | 0 | 1 | 10 | 5 | 11 | 3.98 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 26 | 26 | 5 | 11 | 5.10 | .350 | 1.59 | 10.6 | 3.7 | 9.7 | 164.0 | 193 | 97 | 93 | 26 | 67 | 176 | 1 | 0 | 0 | 1 | 11 | 5 | 2 | 4.23 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 25 | 25 | 3 | 9 | 5.74 | .322 | 1.39 | 10.0 | 2.5 | 5.8 | 117.2 | 130 | 78 | 75 | 20 | 33 | 75 | 0 | 0 | 0 | 0 | 2 | 5 | 1 | 4.91 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 25 | 25 | 7 | 14 | 5.78 | .346 | 1.52 | 10.4 | 3.3 | 6.0 | 143.1 | 165 | 96 | 92 | 18 | 53 | 95 | 1 | 0 | 0 | 0 | 11 | 9 | 2 | 4.61 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 24 | 24 | 10 | 10 | 5.09 | .337 | 1.46 | 10.8 | 2.4 | 7.6 | 146.2 | 175 | 86 | 83 | 19 | 39 | 124 | 0 | 0 | 0 | 0 | 13 | 10 | 5 | 4.00 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 62 | 0 | 5 | 2 | 2.93 | .285 | 1.17 | 6.2 | 4.5 | 9.3 | 95.1 | 65 | 33 | 31 | 4 | 47 | 98 | 0 | 4 | 3 | 0 | 0 | 2 | 0 | 3.03 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 60 | 0 | 4 | 3 | 3.04 | .245 | 0.97 | 6.5 | 2.2 | 6.4 | 77.0 | 56 | 28 | 26 | 6 | 19 | 55 | 0 | 10 | 0 | 0 | 0 | 0 | 1 | 3.32 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 7 | 0 | 2 | 0 | 6.43 | .323 | 1.43 | 5.1 | 7.7 | 3.9 | 7.0 | 4 | 5 | 5 | 2 | 6 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 8.43 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 28 | 0 | 3 | 0 | 1.47 | .236 | 0.93 | 4.8 | 3.8 | 9.5 | 36.2 | 19 | 6 | 6 | 2 | 15 | 38 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.86 |