| SP | Santana, J.Santana, Johan † $$ >> | 25 | 2004 | L | 100 | 26 | 26 | 9 | 9 | 3.25 | .286 | 1.18 | 8.2 | 2.5 | 10.3 | 185.2 | 169 | 69 | 67 | 24 | 51 | 211 | 1 | 0 | 0 | 1 | 19 | 3 | 3 | 3.28 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 49 | 25 | 25 | 9 | 10 | 5.36 | .338 | 1.48 | 10.3 | 3.0 | 6.5 | 149.1 | 171 | 96 | 89 | 22 | 50 | 107 | 0 | 0 | 0 | 0 | 13 | 8 | 5 | 4.65 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 47 | 25 | 25 | 7 | 11 | 6.02 | .340 | 1.52 | 10.0 | 3.7 | 7.0 | 157.0 | 174 | 110 | 105 | 27 | 65 | 122 | 1 | 0 | 0 | 1 | 11 | 4 | 5 | 5.00 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 26 | 25 | 5 | 14 | 5.52 | .363 | 1.67 | 10.3 | 4.7 | 8.1 | 137.0 | 157 | 91 | 84 | 17 | 72 | 123 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 4.50 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 72 | 0 | 4 | 3 | 4.13 | .318 | 1.37 | 7.2 | 5.2 | 9.6 | 93.2 | 74 | 43 | 43 | 9 | 54 | 99 | 0 | 6 | 3 | 0 | 0 | 3 | 2 | 3.97 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 71 | 0 | 5 | 6 | 4.37 | .296 | 1.25 | 9.5 | 1.9 | 8.9 | 92.2 | 97 | 45 | 45 | 13 | 19 | 91 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 3.51 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 50 | 49 | 0 | 4 | 3 | 4.60 | .303 | 1.30 | 8.7 | 3.2 | 7.4 | 60.2 | 58 | 33 | 31 | 8 | 21 | 49 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 4.15 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 45 | 43 | 0 | 4 | 4 | 4.87 | .373 | 1.76 | 10.6 | 5.3 | 7.4 | 44.1 | 52 | 31 | 24 | 7 | 26 | 36 | 0 | 2 | 3 | 0 | 0 | 1 | 2 | 5.27 |
| RP | Aceves, A.Aceves, Alfredo >> | 27 | 2009 | R | 30 | 28 | 0 | 0 | 1 | 3.69 | .331 | 1.42 | 10.2 | 2.9 | 6.4 | 31.2 | 35 | 13 | 13 | 6 | 10 | 22 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 5.26 |
| RP | Otsuka, A.Otsuka, Akinori >> | 32 | 2004 | R | 46 | 22 | 0 | 0 | 3 | 5.33 | .352 | 1.63 | 9.7 | 5.0 | 6.3 | 27.0 | 29 | 17 | 16 | 6 | 15 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.15 |