| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 38 | 38 | 15 | 18 | 3.61 | .287 | 1.16 | 8.2 | 2.3 | 9.2 | 282.0 | 256 | 118 | 113 | 33 | 71 | 288 | 4 | 0 | 0 | 2 | 23 | 14 | 8 | 3.38 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 86 | 37 | 37 | 2 | 8 | 4.65 | .323 | 1.40 | 9.4 | 3.1 | 6.5 | 143.1 | 150 | 74 | 74 | 16 | 50 | 104 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 4.15 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 73 | 35 | 35 | 7 | 8 | 4.68 | .335 | 1.48 | 10.0 | 3.3 | 7.4 | 155.2 | 173 | 82 | 81 | 21 | 57 | 128 | 0 | 0 | 0 | 0 | 1 | 5 | 3 | 4.31 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 34 | 34 | 14 | 13 | 4.14 | .307 | 1.30 | 9.2 | 2.5 | 6.1 | 217.1 | 223 | 111 | 100 | 31 | 60 | 148 | 1 | 0 | 0 | 1 | 20 | 6 | 1 | 4.41 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 55 | 31 | 31 | 13 | 6 | 4.45 | .328 | 1.44 | 9.4 | 3.6 | 7.9 | 180.0 | 188 | 95 | 89 | 30 | 72 | 157 | 0 | 0 | 0 | 0 | 15 | 4 | 7 | 4.69 |
| RP | Benitez, A.Benitez, Armando † >> | 32 | 2004 | R | 91 | 91 | 0 | 19 | 3 | 3.34 | .294 | 1.22 | 7.1 | 3.9 | 7.8 | 126.2 | 100 | 53 | 47 | 14 | 54 | 109 | 0 | 3 | 3 | 0 | 0 | 4 | 0 | 4.10 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 88 | 88 | 0 | 13 | 4 | 3.63 | .304 | 1.29 | 7.0 | 4.6 | 9.1 | 129.0 | 100 | 55 | 52 | 14 | 66 | 131 | 0 | 9 | 6 | 0 | 0 | 3 | 6 | 3.98 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 84 | 0 | 7 | 5 | 2.91 | .287 | 1.13 | 8.3 | 1.9 | 8.4 | 105.1 | 97 | 36 | 34 | 10 | 22 | 98 | 0 | 6 | 1 | 0 | 0 | 8 | 3 | 3.23 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 81 | 0 | 3 | 4 | 2.80 | .268 | 1.09 | 6.3 | 3.5 | 11.5 | 90.0 | 63 | 31 | 28 | 13 | 35 | 115 | 0 | 14 | 1 | 0 | 0 | 1 | 10 | 3.52 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 60 | 0 | 3 | 3 | 4.48 | .332 | 1.44 | 9.5 | 3.5 | 6.9 | 72.1 | 76 | 37 | 36 | 5 | 28 | 55 | 0 | 6 | 0 | 0 | 0 | 4 | 0 | 3.71 |