| SP | Liriano, F.Liriano, Francisco $$ >> | 23 | 2006 | L | 98 | 28 | 28 | 4 | 8 | 4.84 | .322 | 1.41 | 9.1 | 3.6 | 9.1 | 126.1 | 127 | 72 | 68 | 17 | 51 | 127 | 0 | 0 | 0 | 0 | 1 | 2 | 10 | 4.00 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 27 | 27 | 15 | 9 | 5.94 | .338 | 1.49 | 9.8 | 3.6 | 10.0 | 162.0 | 177 | 108 | 107 | 26 | 65 | 180 | 0 | 0 | 0 | 0 | 11 | 6 | 1 | 4.18 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 27 | 27 | 8 | 5 | 3.60 | .328 | 1.42 | 9.2 | 3.5 | 6.7 | 120.0 | 123 | 52 | 48 | 12 | 47 | 89 | 0 | 0 | 0 | 0 | 3 | 6 | 0 | 4.14 |
| SP | Nolasco, R.Nolasco, Ricky >> | 26 | 2008 | R | 56 | 27 | 27 | 10 | 13 | 6.08 | .343 | 1.53 | 11.2 | 2.6 | 6.4 | 164.1 | 204 | 114 | 111 | 37 | 48 | 117 | 0 | 0 | 0 | 0 | 11 | 5 | 4 | 5.48 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 75 | 0 | 10 | 2 | 2.79 | .265 | 1.06 | 7.0 | 2.5 | 8.5 | 119.1 | 93 | 37 | 37 | 11 | 33 | 112 | 0 | 3 | 3 | 0 | 0 | 3 | 4 | 3.23 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 74 | 0 | 11 | 4 | 3.19 | .280 | 1.15 | 7.4 | 2.9 | 6.6 | 107.1 | 88 | 41 | 38 | 16 | 35 | 78 | 0 | 5 | 3 | 0 | 0 | 2 | 1 | 4.52 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 67 | 0 | 5 | 1 | 3.64 | .321 | 1.38 | 8.9 | 3.7 | 8.6 | 81.2 | 80 | 35 | 33 | 9 | 33 | 77 | 0 | 8 | 2 | 0 | 0 | 3 | 0 | 3.88 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 60 | 0 | 4 | 2 | 2.15 | .236 | 0.89 | 5.8 | 2.3 | 8.4 | 79.2 | 51 | 25 | 19 | 5 | 20 | 74 | 0 | 13 | 3 | 0 | 0 | 3 | 6 | 2.82 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 31 | 0 | 2 | 2 | 4.05 | .333 | 1.47 | 8.7 | 4.6 | 6.0 | 33.1 | 32 | 18 | 15 | 5 | 17 | 22 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 5.27 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 37 | 0 | 1 | 1 | 3.15 | .315 | 1.34 | 10.6 | 1.6 | 7.2 | 45.2 | 53 | 16 | 16 | 4 | 8 | 36 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.22 |