| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 34 | 34 | 15 | 13 | 4.07 | .300 | 1.23 | 8.1 | 3.0 | 10.0 | 258.2 | 232 | 126 | 117 | 35 | 85 | 286 | 8 | 0 | 0 | 3 | 21 | 15 | 6 | 3.71 |
| SP | Loaiza, E.Loaiza, Esteban >> | 32 | 2003 | R | 58 | 33 | 33 | 11 | 17 | 5.35 | .333 | 1.44 | 10.1 | 2.9 | 6.1 | 208.2 | 233 | 133 | 124 | 37 | 68 | 142 | 2 | 0 | 0 | 0 | 13 | 12 | 4 | 5.10 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 54 | 32 | 32 | 11 | 17 | 5.50 | .332 | 1.48 | 10.3 | 3.0 | 9.0 | 185.0 | 211 | 119 | 113 | 37 | 62 | 185 | 0 | 0 | 0 | 0 | 15 | 3 | 3 | 4.65 |
| SP | Shields, J.Shields, James † >> | 26 | 2007 | R | 52 | 32 | 32 | 13 | 10 | 4.79 | .321 | 1.39 | 9.8 | 2.7 | 7.6 | 199.1 | 217 | 117 | 106 | 31 | 60 | 167 | 0 | 0 | 0 | 0 | 17 | 6 | 9 | 4.34 |
| SP | Patterson, J.Patterson, John >> | 27 | 2005 | R | 32 | 31 | 31 | 13 | 12 | 4.67 | .308 | 1.31 | 8.7 | 3.1 | 7.6 | 190.2 | 184 | 108 | 99 | 32 | 66 | 161 | 0 | 0 | 0 | 0 | 13 | 5 | 9 | 4.62 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 87 | 0 | 3 | 2 | 3.59 | .281 | 1.14 | 7.0 | 3.2 | 9.2 | 115.1 | 90 | 50 | 46 | 12 | 41 | 118 | 0 | 7 | 4 | 0 | 0 | 4 | 2 | 3.48 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 87 | 75 | 0 | 1 | 4 | 3.36 | .316 | 1.34 | 7.6 | 4.5 | 6.3 | 91.0 | 77 | 36 | 34 | 6 | 45 | 64 | 0 | 7 | 2 | 0 | 0 | 4 | 0 | 4.07 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 56 | 60 | 0 | 2 | 1 | 4.22 | .356 | 1.64 | 8.7 | 6.3 | 7.9 | 59.2 | 57 | 30 | 28 | 12 | 41 | 52 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 6.02 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 53 | 42 | 0 | 1 | 3 | 8.60 | .381 | 1.84 | 11.6 | 5.0 | 10.6 | 45.0 | 58 | 44 | 43 | 10 | 25 | 53 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.20 |
| SP | Perez, O.Perez, Oliver >> | 23 | 2004 | L | 75 | 21 | 0 | 2 | 3 | 3.00 | .299 | 1.28 | 7.5 | 4.0 | 10.0 | 36.0 | 30 | 18 | 12 | 5 | 16 | 40 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.92 |