| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 29 | 29 | 9 | 13 | 4.60 | .295 | 1.23 | 9.2 | 2.0 | 10.7 | 156.2 | 159 | 81 | 80 | 25 | 34 | 185 | 1 | 0 | 0 | 1 | 10 | 4 | 1 | 3.44 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 88 | 28 | 28 | 7 | 14 | 4.62 | .331 | 1.45 | 9.6 | 3.5 | 10.2 | 156.0 | 166 | 83 | 80 | 19 | 60 | 176 | 0 | 0 | 0 | 0 | 10 | 6 | 2 | 3.60 |
| SP | Valdez, F.Valdez, Framber >> | 31 | 2025 | L | 57 | 29 | 27 | 8 | 9 | 6.51 | .354 | 1.60 | 9.9 | 4.5 | 7.9 | 141.0 | 155 | 107 | 102 | 27 | 70 | 123 | 1 | 0 | 1 | 0 | 7 | 7 | 13 | 5.38 |
| CL | Okert, S.Okert, Steven >> | 33 | 2025 | L | 97 | 83 | 0 | 2 | 3 | 4.31 | .304 | 1.24 | 8.1 | 3.1 | 10.1 | 102.1 | 92 | 52 | 49 | 11 | 35 | 114 | 0 | 12 | 6 | 0 | 0 | 7 | 0 | 3.40 |
| SU | Fisher, B.Fisher, Braydon >> | 24 | 2025 | R | 88 | 78 | 0 | 2 | 5 | 4.58 | .316 | 1.34 | 8.4 | 3.7 | 10.4 | 98.1 | 92 | 54 | 50 | 10 | 40 | 113 | 0 | 3 | 6 | 0 | 0 | 4 | 0 | 3.37 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 96 | 0 | 7 | 3 | 4.41 | .329 | 1.38 | 7.9 | 4.6 | 7.2 | 104.0 | 91 | 52 | 51 | 9 | 53 | 83 | 0 | 6 | 4 | 0 | 0 | 9 | 10 | 4.32 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 75 | 86 | 0 | 4 | 1 | 4.61 | .323 | 1.39 | 8.4 | 4.2 | 7.6 | 93.2 | 87 | 48 | 48 | 16 | 43 | 79 | 0 | 5 | 3 | 0 | 0 | 4 | 3 | 5.05 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 68 | 79 | 0 | 5 | 4 | 4.12 | .324 | 1.36 | 7.3 | 5.0 | 7.4 | 94.0 | 76 | 45 | 43 | 9 | 52 | 77 | 0 | 5 | 0 | 0 | 0 | 7 | 3 | 4.49 |