| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 36 | 36 | 17 | 10 | 3.70 | .279 | 1.14 | 8.3 | 2.0 | 10.0 | 233.1 | 215 | 97 | 96 | 29 | 52 | 258 | 1 | 0 | 0 | 1 | 22 | 4 | 6 | 3.12 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 86 | 34 | 34 | 16 | 7 | 4.21 | .315 | 1.35 | 8.0 | 4.2 | 9.7 | 184.0 | 163 | 89 | 86 | 22 | 85 | 198 | 0 | 0 | 0 | 0 | 10 | 6 | 6 | 3.89 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 78 | 34 | 33 | 9 | 11 | 4.46 | .322 | 1.41 | 9.5 | 3.3 | 7.5 | 155.1 | 163 | 79 | 77 | 22 | 56 | 130 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 4.29 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 63 | 32 | 32 | 11 | 10 | 5.15 | .338 | 1.46 | 10.1 | 3.1 | 11.1 | 174.2 | 195 | 102 | 100 | 28 | 60 | 215 | 0 | 0 | 0 | 0 | 14 | 12 | 4 | 3.86 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 56 | 32 | 32 | 6 | 7 | 3.96 | .333 | 1.47 | 9.9 | 3.4 | 9.8 | 143.1 | 157 | 64 | 63 | 10 | 54 | 155 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | 2.96 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 92 | 89 | 0 | 9 | 7 | 3.42 | .287 | 1.17 | 7.6 | 2.9 | 8.2 | 121.0 | 102 | 46 | 46 | 10 | 39 | 110 | 0 | 4 | 3 | 0 | 0 | 5 | 0 | 3.35 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 65 | 81 | 0 | 6 | 2 | 4.71 | .344 | 1.53 | 8.1 | 5.8 | 7.6 | 86.0 | 77 | 47 | 45 | 17 | 55 | 73 | 0 | 2 | 3 | 0 | 0 | 3 | 1 | 5.90 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 79 | 0 | 6 | 7 | 3.67 | .309 | 1.31 | 7.8 | 4.0 | 12.3 | 83.1 | 72 | 36 | 34 | 10 | 37 | 113 | 0 | 34 | 6 | 0 | 0 | 3 | 6 | 3.29 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 90 | 86 | 0 | 4 | 6 | 3.29 | .262 | 1.06 | 6.2 | 3.4 | 9.8 | 95.2 | 65 | 38 | 35 | 11 | 36 | 103 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 3.51 |