| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 8 | 8 | 3 | 3 | 5.64 | .340 | 1.54 | 11.3 | 2.9 | 12.3 | 44.2 | 55 | 28 | 28 | 7 | 14 | 60 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 3.30 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 86 | 8 | 8 | 2 | 4 | 6.81 | .393 | 1.84 | 12.6 | 3.9 | 8.5 | 37.0 | 52 | 31 | 28 | 7 | 16 | 35 | 0 | 0 | 0 | 0 | 1 | 4 | 2 | 5.19 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 78 | 9 | 8 | 4 | 2 | 3.57 | .309 | 1.34 | 8.8 | 3.4 | 6.3 | 40.1 | 39 | 16 | 16 | 4 | 15 | 28 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 4.03 |
| SP | Luzardo, J.Luzardo, Jesus >> | 27 | 2025 | L | 63 | 8 | 8 | 4 | 1 | 2.66 | .324 | 1.35 | 8.6 | 3.6 | 12.4 | 47.1 | 45 | 14 | 14 | 5 | 19 | 65 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 3.09 |
| SP | Burrows, M.Burrows, Mike >> | 25 | 2025 | R | 56 | 7 | 7 | 1 | 0 | 3.98 | .312 | 1.36 | 8.4 | 4.1 | 10.5 | 31.2 | 29 | 15 | 14 | 4 | 14 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.71 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 92 | 21 | 0 | 3 | 2 | 3.52 | .220 | 0.78 | 5.4 | 1.8 | 6.9 | 30.2 | 18 | 12 | 12 | 2 | 6 | 23 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.13 |
| RP | Rodríguez, Y.Rodríguez, Yariel >> | 28 | 2025 | R | 65 | 15 | 0 | 2 | 1 | 6.27 | .356 | 1.61 | 9.5 | 5.5 | 5.5 | 18.2 | 19 | 13 | 13 | 1 | 11 | 11 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 4.50 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 18 | 0 | 2 | 1 | 4.42 | .321 | 1.36 | 8.5 | 4.0 | 13.5 | 18.1 | 17 | 10 | 9 | 4 | 8 | 27 | 0 | 9 | 2 | 0 | 0 | 1 | 2 | 4.39 |
| SU | Jansen, K.Jansen, Kenley >> | 37 | 2025 | R | 90 | 18 | 0 | 0 | 1 | 0.83 | .217 | 0.83 | 6.0 | 1.7 | 11.1 | 21.2 | 14 | 2 | 2 | 2 | 4 | 26 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.33 |