| SP | Clemens, R.Clemens, Roger # >> | 43 | 2005 | R | 94 | 19 | 19 | 7 | 7 | 3.50 | .283 | 1.17 | 8.3 | 2.3 | 6.8 | 128.2 | 118 | 51 | 50 | 12 | 33 | 96 | 0 | 0 | 0 | 0 | 13 | 1 | 0 | 3.52 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 18 | 18 | 4 | 9 | 6.14 | .351 | 1.59 | 8.7 | 5.5 | 6.8 | 104.0 | 101 | 72 | 71 | 20 | 64 | 78 | 0 | 0 | 0 | 0 | 6 | 4 | 5 | 5.96 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 17 | 17 | 8 | 7 | 5.11 | .330 | 1.44 | 10.4 | 2.5 | 6.3 | 100.1 | 116 | 60 | 57 | 15 | 28 | 70 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 4.51 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 50 | 17 | 17 | 3 | 11 | 7.96 | .364 | 1.64 | 11.7 | 3.1 | 6.9 | 95.0 | 123 | 86 | 84 | 15 | 33 | 73 | 0 | 0 | 0 | 0 | 3 | 7 | 0 | 4.78 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 50 | 0 | 1 | 3 | 3.68 | .315 | 1.35 | 9.9 | 2.4 | 9.9 | 63.2 | 69 | 26 | 26 | 9 | 17 | 69 | 0 | 8 | 1 | 0 | 0 | 2 | 0 | 3.57 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 28 | 0 | 3 | 4 | 5.46 | .339 | 1.46 | 8.7 | 4.5 | 10.0 | 28.0 | 27 | 18 | 17 | 4 | 14 | 31 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 4.36 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 47 | 17 | 0 | 0 | 0 | 4.12 | .322 | 1.37 | 8.1 | 4.7 | 6.6 | 19.2 | 17 | 11 | 9 | 4 | 10 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.00 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 45 | 21 | 0 | 0 | 0 | 3.28 | .333 | 1.42 | 9.4 | 3.8 | 6.0 | 24.2 | 25 | 9 | 9 | 3 | 10 | 16 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.79 |